biostudies-literatureYu UShenzhen Children&apos;s Hospital Research FundShenzhen Fund for Guangdong Provincial High-level Clinical Key SpecialtiesShenzhen Science and Technology programShenzhen Children's Hospital Research FundShenzhen Key Medical Discipline Construction FundSanming Project of Medicine in ShenzhenShenzhen Healthcare Research Project1309-1322https://www.ebi.ac.uk/biostudies/studies/S-EPMC8322184biostudies-literatureUnknown10(3)<h4>Introduction</h4>Drug-resistant cytomegalovirus (CMV) infection remains a challenge in the management of pediatric recipients of hematopoietic stem cell transplantation (HSCT). In this study, we retrospectively reviewed the clinical data on pediatric recipients of HSCT and identified known and unknown drug-resistant CMV variants.<h4>Methods</h4>A total of 221 children underwent allogeneic HSCT between October 2017 and November 2019 at Shenzhen Children's Hospital; of these, 35 patients were suspected of having drug-resistant CMV infections and were tested for drug-resistant mutations in the UL97 and UL54 genes by Sanger sequencing.<h4>Results</h4>Mutations in UL97 or UL54, or in both, were detected in 11 patients. Most of these mutations have not been previously reported. The UL97 mutaInfectious diseases and therapyCytomegalovirus Infection and the Implications of Drug-Resistant Mutations in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Retrospective Study from a Tertiary Hospital in China.PMC8322184SZXK034SZLY2018015SZSM 201512033SZGSP012RCBS20200714114858018ynkt2020-zz01Li YWen JWang CZhang XHuang XYu UWang XLiu SYang CZhou XWen FfalseCytomegalovirus Infection and the Implications of Drug-Resistant Mutations in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Retrospective Study from a Tertiary Hospital in China.<h4>Introduction</h4>Drug-resistant cytomegalovirus (CMV) infection remains a challenge in the management of pediatric recipients of hematopoietic stem cell transplantation (HSCT). In this study, we retrospectively reviewed the clinical data on pediatric recipients of HSCT and identified known and unknown drug-resistant CMV variants.<h4>Methods</h4>A total of 221 children underwent allogeneic HSCT between October 2017 and November 2019 at Shenzhen Children's Hospital; of these, 35 patients were suspected of having drug-resistant CMV infections and were tested for drug-resistant mutations in the UL97 and UL54 genes by Sanger sequencing.<h4>Results</h4>Mutations in UL97 or UL54, or in both, were detected in 11 patients. Most of these mutations have not been previously reported. The UL97 muta2021-01-01T00:00:00Z2021 Sep2025-04-19T20:39:44.788Z2022-02-11T08:23:13.817ZS-EPMC83221843396617610.1007/s40121-021-00452-4