{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(7)"],"submitter":["Kumara K"],"pubmed_abstract":["In a sustained search for novel and effective antioxidants, a potential therapeutic leads against renal, and neurological disorders. Amongst the heterocycles, pyrazole and their derivatives have been extensively studied for their biological potencies, particularly to a larger extent for their antioxidant properties. Although many of pyrazole derivatives displayed antioxidant activities, still there is a need of developing efficient protocol for their synthesis, involving ecofriendly conditions, molecules of greater antioxidant efficacy and lesser toxicity, etc. In this context, the current study presents an amberlyst-15 catalysed efficient synthesis of 2-pyrazoline derivatives, <b>5</b>(<b>a</b>-<b>g</b>) via (3 + 2) annulation of chalcones with phenylhydrazines. Structure proofs of new py"],"journal":["Heliyon"],"pagination":["e07592"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8322289"],"repository":["biostudies-literature"],"pubmed_title":["Design, synthesis, characterization, and antioxidant activity studies of novel thienyl-pyrazoles."],"pmcid":["PMC8322289"],"pubmed_authors":["Lokanath NK","Prabhudeva MG","Kumara K","Vivek HK","Ajay Kumar K","Vagish CB","Lokanatha Rai KM"],"additional_accession":[]},"is_claimable":false,"name":"Design, synthesis, characterization, and antioxidant activity studies of novel thienyl-pyrazoles.","description":"In a sustained search for novel and effective antioxidants, a potential therapeutic leads against renal, and neurological disorders. Amongst the heterocycles, pyrazole and their derivatives have been extensively studied for their biological potencies, particularly to a larger extent for their antioxidant properties. Although many of pyrazole derivatives displayed antioxidant activities, still there is a need of developing efficient protocol for their synthesis, involving ecofriendly conditions, molecules of greater antioxidant efficacy and lesser toxicity, etc. In this context, the current study presents an amberlyst-15 catalysed efficient synthesis of 2-pyrazoline derivatives, <b>5</b>(<b>a</b>-<b>g</b>) via (3 + 2) annulation of chalcones with phenylhydrazines. Structure proofs of new py","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2025-04-18T11:18:45.945Z","creation":"2022-02-11T05:16:30.876Z"},"accession":"S-EPMC8322289","cross_references":{"pubmed":["34355092"],"doi":["10.1016/j.heliyon.2021.e07592"]}}