biostudies-literatureUnknown7(7)Kumara KIn a sustained search for novel and effective antioxidants, a potential therapeutic leads against renal, and neurological disorders. Amongst the heterocycles, pyrazole and their derivatives have been extensively studied for their biological potencies, particularly to a larger extent for their antioxidant properties. Although many of pyrazole derivatives displayed antioxidant activities, still there is a need of developing efficient protocol for their synthesis, involving ecofriendly conditions, molecules of greater antioxidant efficacy and lesser toxicity, etc. In this context, the current study presents an amberlyst-15 catalysed efficient synthesis of 2-pyrazoline derivatives, <b>5</b>(<b>a</b>-<b>g</b>) via (3 + 2) annulation of chalcones with phenylhydrazines. Structure proofs of new pyHeliyone07592https://www.ebi.ac.uk/biostudies/studies/S-EPMC8322289biostudies-literatureDesign, synthesis, characterization, and antioxidant activity studies of novel thienyl-pyrazoles.PMC8322289Lokanath NKPrabhudeva MGKumara KVivek HKAjay Kumar KVagish CBLokanatha Rai KMfalseDesign, synthesis, characterization, and antioxidant activity studies of novel thienyl-pyrazoles.In a sustained search for novel and effective antioxidants, a potential therapeutic leads against renal, and neurological disorders. Amongst the heterocycles, pyrazole and their derivatives have been extensively studied for their biological potencies, particularly to a larger extent for their antioxidant properties. Although many of pyrazole derivatives displayed antioxidant activities, still there is a need of developing efficient protocol for their synthesis, involving ecofriendly conditions, molecules of greater antioxidant efficacy and lesser toxicity, etc. In this context, the current study presents an amberlyst-15 catalysed efficient synthesis of 2-pyrazoline derivatives, <b>5</b>(<b>a</b>-<b>g</b>) via (3 + 2) annulation of chalcones with phenylhydrazines. Structure proofs of new py2021-01-01T00:00:00Z2021 Jul2025-04-18T11:18:45.945Z2022-02-11T05:16:30.876ZS-EPMC83222893435509210.1016/j.heliyon.2021.e07592