{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kaplan AR"],"funding":["Division of Chemistry","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["544-551"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8322966"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(3)"],"pubmed_abstract":["<i>Pseudomonads</i> employ several strategies to sequester iron vital for their survival including the use of siderophores such as pyoverdine and pyochelin. Similar in structure but significantly less studied are pyochelin biosynthetic byproducts, dihydroaeruginoic acid, aeruginoic acid, aeruginaldehyde (IQS), and aeruginol, along with two other structurally related molecules, aerugine and pyonitrins A-D, which have all been isolated from numerous <i>Pseudomonad</i> extracts. Because of the analogous substructure of these compounds to pyochelin, we hypothesized that they may play a role in iron homeostasis or have a biological effect on other bacterial species. Herein, we discuss the physiochemical evaluation of these molecules and disclose, for the first time, their ability to bind iron a"],"journal":["ACS infectious diseases"],"pubmed_title":["Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth in <i>Pseudomonads</i> Demonstrating Siderophore-like Activity."],"pmcid":["PMC8322966"],"funding_grant_id":["CHE0958205","R35 GM119426","GM119426","DGE1937971","CHE2003692"],"pubmed_authors":["Musaev DG","Wuest WM","Kaplan AR"],"additional_accession":[]},"is_claimable":false,"name":"Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth in <i>Pseudomonads</i> Demonstrating Siderophore-like Activity.","description":"<i>Pseudomonads</i> employ several strategies to sequester iron vital for their survival including the use of siderophores such as pyoverdine and pyochelin. Similar in structure but significantly less studied are pyochelin biosynthetic byproducts, dihydroaeruginoic acid, aeruginoic acid, aeruginaldehyde (IQS), and aeruginol, along with two other structurally related molecules, aerugine and pyonitrins A-D, which have all been isolated from numerous <i>Pseudomonad</i> extracts. Because of the analogous substructure of these compounds to pyochelin, we hypothesized that they may play a role in iron homeostasis or have a biological effect on other bacterial species. Herein, we discuss the physiochemical evaluation of these molecules and disclose, for the first time, their ability to bind iron a","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-05-09T17:15:28.919Z","creation":"2022-02-11T00:54:49.963Z"},"accession":"S-EPMC8322966","cross_references":{"pubmed":["33577297"],"doi":["10.1021/acsinfecdis.0c00897"]}}