{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["129(7)"],"submitter":["Li B"],"pubmed_abstract":["<h4>Background</h4>Global concerns of methylmercury (MeHg) exposure have been raised, especially on its effects on pregnant women. Recent epidemiological studies have revealed associations between maternal blood/hair MeHg concentrations, adverse pregnancy outcomes, and developmental deficits. However, the underlying mechanisms remain unclear.<h4>Objectives</h4>In this study, we characterized the effects of MeHg exposure on undifferentiated human embryonic stem cells (hESCs) and extrapolated the effects to human embryonic development.<h4>Methods</h4>hESCs were exposed to 0, 1, 5, 10, 50, 100 or 200nM MeHg for 24 h or 6 d. Cell adherence and colony formation and expansion were examined under the microscope. Cell attachment, viability/proliferation, apoptosis, stress response, cell cycle, aut"],"journal":["Environmental health perspectives"],"pagination":["77007"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8323991"],"repository":["biostudies-literature"],"pubmed_title":["Characterizing the Low-Dose Effects of Methylmercury on the Early Stages of Embryo Development Using Cultured Human Embryonic Stem Cells."],"pmcid":["PMC8323991"],"pubmed_authors":["Chan HM","Jin X","Qiao C","Li B"],"additional_accession":[]},"is_claimable":false,"name":"Characterizing the Low-Dose Effects of Methylmercury on the Early Stages of Embryo Development Using Cultured Human Embryonic Stem Cells.","description":"<h4>Background</h4>Global concerns of methylmercury (MeHg) exposure have been raised, especially on its effects on pregnant women. Recent epidemiological studies have revealed associations between maternal blood/hair MeHg concentrations, adverse pregnancy outcomes, and developmental deficits. However, the underlying mechanisms remain unclear.<h4>Objectives</h4>In this study, we characterized the effects of MeHg exposure on undifferentiated human embryonic stem cells (hESCs) and extrapolated the effects to human embryonic development.<h4>Methods</h4>hESCs were exposed to 0, 1, 5, 10, 50, 100 or 200nM MeHg for 24 h or 6 d. Cell adherence and colony formation and expansion were examined under the microscope. Cell attachment, viability/proliferation, apoptosis, stress response, cell cycle, aut","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2025-06-01T03:45:20.939Z","creation":"2025-06-01T03:45:20.939Z"},"accession":"S-EPMC8323991","cross_references":{"pubmed":["34328791"],"doi":["10.1289/EHP7349"]}}