{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Brouwer E"],"funding":["Dutch Research Council (NWO)"],"pubmed_abstract":["<b>Background:</b> Cardiovascular changes during the transition from intra- to extrauterine life, alters the pressure gradient across the ductus arteriosus (DA). DA flow ratio (R-L/L-R) has been suggested to reflect the infant's transitional status and could potentially predict neonatal outcomes after preterm birth. <b>Aim:</b> Determine whether DA flow ratio correlates with oxygenation parameters in preterm infants at 1 h after birth. <b>Methods:</b> Echocardiography was performed in preterm infants born <32 weeks gestational age (GA), as part of an ancillary study. DA flow was measured at 1 h after birth. DA flow ratio was correlated with FiO<sub>2</sub>, SpO<sub>2</sub>, and SpO<sub>2</sub>/FiO<sub>2</sub> (SF) ratio. The DA flow ratio of infants receiving physiological-based cord clamping (PBCC) or time-based cord clamping (TBCC) were compared. <b>Results:</b> Measurements from 16 infants were analysed (median [IQR] GA 29 [27-30] weeks; birthweight 1,176 [951-1,409] grams). R-L DA shunting was 16 [17-27] ml/kg/min and L-R was 110 [81-124] ml/kg/min. The DA flow ratio was 0.18 [0.11-0.28], SpO<sub>2</sub> 94 [93-96]%, FiO<sub>2</sub> was 23 [21-28]% and SF ratio 4.1 [3.3-4.5]. There was a moderate correlation between DA flow ratio and SpO<sub>2</sub> [correlation coefficient (CC) -0.415; <i>p</i> = 0.110], FiO<sub>2</sub> (CC 0.384; <i>p</i> = 0.142) and SF ratio (CC -0.356; <i>p</i> = 0.175). There were no differences in DA flow measurements between infants where PBBC or TBCC was performed. <b>Conclusion:</b> In this pilot study we observed a non-significant positive correlation between DA flow ratio at 1 h after birth and oxygenation parameters in preterm infants."],"journal":["Frontiers in pediatrics"],"pagination":["668744"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8326397"],"repository":["biostudies-literature"],"pubmed_title":["Ductal Flow Ratio as Measure of Transition in Preterm Infants After Birth: A Pilot Study."],"pmcid":["PMC8326397"],"pubmed_authors":["Hahurij ND","Brouwer E","Roest AAW","Hooper SB","Knol R","Te Pas AB"],"additional_accession":[]},"is_claimable":false,"name":"Ductal Flow Ratio as Measure of Transition in Preterm Infants After Birth: A Pilot Study.","description":"<b>Background:</b> Cardiovascular changes during the transition from intra- to extrauterine life, alters the pressure gradient across the ductus arteriosus (DA). DA flow ratio (R-L/L-R) has been suggested to reflect the infant's transitional status and could potentially predict neonatal outcomes after preterm birth. <b>Aim:</b> Determine whether DA flow ratio correlates with oxygenation parameters in preterm infants at 1 h after birth. <b>Methods:</b> Echocardiography was performed in preterm infants born <32 weeks gestational age (GA), as part of an ancillary study. DA flow was measured at 1 h after birth. DA flow ratio was correlated with FiO<sub>2</sub>, SpO<sub>2</sub>, and SpO<sub>2</sub>/FiO<sub>2</sub> (SF) ratio. The DA flow ratio of infants receiving physiological-based cord clamping (PBCC) or time-based cord clamping (TBCC) were compared. <b>Results:</b> Measurements from 16 infants were analysed (median [IQR] GA 29 [27-30] weeks; birthweight 1,176 [951-1,409] grams). R-L DA shunting was 16 [17-27] ml/kg/min and L-R was 110 [81-124] ml/kg/min. The DA flow ratio was 0.18 [0.11-0.28], SpO<sub>2</sub> 94 [93-96]%, FiO<sub>2</sub> was 23 [21-28]% and SF ratio 4.1 [3.3-4.5]. There was a moderate correlation between DA flow ratio and SpO<sub>2</sub> [correlation coefficient (CC) -0.415; <i>p</i> = 0.110], FiO<sub>2</sub> (CC 0.384; <i>p</i> = 0.142) and SF ratio (CC -0.356; <i>p</i> = 0.175). There were no differences in DA flow measurements between infants where PBBC or TBCC was performed. <b>Conclusion:</b> In this pilot study we observed a non-significant positive correlation between DA flow ratio at 1 h after birth and oxygenation parameters in preterm infants.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-20T01:07:09.341Z","creation":"2022-02-11T04:22:40.852Z"},"accession":"S-EPMC8326397","cross_references":{"pubmed":["34350143"],"doi":["10.3389/fped.2021.668744"]}}