biostudies-literatureUnknown9Brouwer EDutch Research Council (NWO)<b>Background:</b> Cardiovascular changes during the transition from intra- to extrauterine life, alters the pressure gradient across the ductus arteriosus (DA). DA flow ratio (R-L/L-R) has been suggested to reflect the infant's transitional status and could potentially predict neonatal outcomes after preterm birth. <b>Aim:</b> Determine whether DA flow ratio correlates with oxygenation parameters in preterm infants at 1 h after birth. <b>Methods:</b> Echocardiography was performed in preterm infants born <32 weeks gestational age (GA), as part of an ancillary study. DA flow was measured at 1 h after birth. DA flow ratio was correlated with FiO₂, SpO₂, and SpO₂/FiO₂ (SF) ratio. The DA flow ratio of infants receiving physiological-based cord clamping (PBCC) or time-based cord clamping (TBCC) were compared. <b>Results:</b> Measurements from 16 infants were analysed (median [IQR] GA 29 [27-30] weeks; birthweight 1,176 [951-1,409] grams). R-L DA shunting was 16 [17-27] ml/kg/min and L-R was 110 [81-124] ml/kg/min. The DA flow ratio was 0.18 [0.11-0.28], SpO₂ 94 [93-96]%, FiO₂ was 23 [21-28]% and SF ratio 4.1 [3.3-4.5]. There was a moderate correlation between DA flow ratio and SpO₂ [correlation coefficient (CC) -0.415; <i>p</i> = 0.110], FiO₂ (CC 0.384; <i>p</i> = 0.142) and SF ratio (CC -0.356; <i>p</i> = 0.175). There were no differences in DA flow measurements between infants where PBBC or TBCC was performed. <b>Conclusion:</b> In this pilot study we observed a non-significant positive correlation between DA flow ratio at 1 h after birth and oxygenation parameters in preterm infants.Frontiers in pediatrics668744https://www.ebi.ac.uk/biostudies/studies/S-EPMC8326397biostudies-literatureDuctal Flow Ratio as Measure of Transition in Preterm Infants After Birth: A Pilot Study.PMC8326397Hahurij NDBrouwer ERoest AAWHooper SBKnol RTe Pas ABfalseDuctal Flow Ratio as Measure of Transition in Preterm Infants After Birth: A Pilot Study.<b>Background:</b> Cardiovascular changes during the transition from intra- to extrauterine life, alters the pressure gradient across the ductus arteriosus (DA). DA flow ratio (R-L/L-R) has been suggested to reflect the infant's transitional status and could potentially predict neonatal outcomes after preterm birth. <b>Aim:</b> Determine whether DA flow ratio correlates with oxygenation parameters in preterm infants at 1 h after birth. <b>Methods:</b> Echocardiography was performed in preterm infants born <32 weeks gestational age (GA), as part of an ancillary study. DA flow was measured at 1 h after birth. DA flow ratio was correlated with FiO₂, SpO₂, and SpO₂/FiO₂ (SF) ratio. The DA flow ratio of infants receiving physiological-based cord clamping (PBCC) or time-based cord clamping (TBCC) were compared. <b>Results:</b> Measurements from 16 infants were analysed (median [IQR] GA 29 [27-30] weeks; birthweight 1,176 [951-1,409] grams). R-L DA shunting was 16 [17-27] ml/kg/min and L-R was 110 [81-124] ml/kg/min. The DA flow ratio was 0.18 [0.11-0.28], SpO₂ 94 [93-96]%, FiO₂ was 23 [21-28]% and SF ratio 4.1 [3.3-4.5]. There was a moderate correlation between DA flow ratio and SpO₂ [correlation coefficient (CC) -0.415; <i>p</i> = 0.110], FiO₂ (CC 0.384; <i>p</i> = 0.142) and SF ratio (CC -0.356; <i>p</i> = 0.175). There were no differences in DA flow measurements between infants where PBBC or TBCC was performed. <b>Conclusion:</b> In this pilot study we observed a non-significant positive correlation between DA flow ratio at 1 h after birth and oxygenation parameters in preterm infants.2021-01-01T00:00:00Z20212025-04-20T01:07:09.341Z2022-02-11T04:22:40.852ZS-EPMC83263973435014310.3389/fped.2021.668744