{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Li Y"],"pubmed_abstract":["<h4>Background</h4>Quiescin Q6 sulfhydryl oxidase 2 (QSOX2), an enzyme that can be directly secreted into the extracellular space, is known to be associated with oxidative protein folding. However, whether <i>QSOX2</i> is abnormally expressed in non-small cell lung cancer (NSCLC) and its role in tumor growth remains unclear.<h4>Methods</h4>Real-time quantitative PCR (qPCR), immunohistochemistry (IHC), bioinformatics analyses were applied to analyze the expression pattern and prognostic significance of QSOX2 in NSCLC. Xenografts model, enzyme-linked immunosorbent assays (ELISA), western blot analysis (WB), and IHC were preformed to examine <i>in vivo</i> tumor suppression and intracellular and extracellular expression of QSOX2. Flow cytometry, WB and qPCR analyses were used to elucidate the"],"journal":["Frontiers in cell and developmental biology"],"pagination":["688798"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8326667"],"repository":["biostudies-literature"],"pubmed_title":["QSOX2 Is an E2F1 Target Gene and a Novel Serum Biomarker for Monitoring Tumor Growth and Predicting Survival in Advanced NSCLC."],"pmcid":["PMC8326667"],"pubmed_authors":["Liu H","Xiong J","Li Y","Liu M","Zhang Z","Shi C","Deng L","Zhai Z","Wang Y","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"QSOX2 Is an E2F1 Target Gene and a Novel Serum Biomarker for Monitoring Tumor Growth and Predicting Survival in Advanced NSCLC.","description":"<h4>Background</h4>Quiescin Q6 sulfhydryl oxidase 2 (QSOX2), an enzyme that can be directly secreted into the extracellular space, is known to be associated with oxidative protein folding. However, whether <i>QSOX2</i> is abnormally expressed in non-small cell lung cancer (NSCLC) and its role in tumor growth remains unclear.<h4>Methods</h4>Real-time quantitative PCR (qPCR), immunohistochemistry (IHC), bioinformatics analyses were applied to analyze the expression pattern and prognostic significance of QSOX2 in NSCLC. Xenografts model, enzyme-linked immunosorbent assays (ELISA), western blot analysis (WB), and IHC were preformed to examine <i>in vivo</i> tumor suppression and intracellular and extracellular expression of QSOX2. Flow cytometry, WB and qPCR analyses were used to elucidate the","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-08T12:39:19.916Z","creation":"2022-02-11T04:28:47.562Z"},"accession":"S-EPMC8326667","cross_references":{"pubmed":["34350181"],"doi":["10.3389/fcell.2021.688798"]}}