{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Lou TL"],"pubmed_abstract":["<i>Tetrastigma hemsleyanum</i> Diels & Gilg (<i>T. hemsleyanum</i>) has attracted much attention due to its ability on pneumonia, bronchitis, and immune-related diseases, while its functional components and underlying mechanism of action on pneumonia have not been fully elucidated. Herein, we used a systematic network pharmacology approach to explore the action mechanism of <i>T. hemsleyanum</i> leaf in the treatment of pneumonia. In this study, the results of network pharmacology demonstrated that there were 34 active components and 80 drug-disease targets in <i>T. hemsleyanum</i> leaf, which were strongly in connection with signal transduction, inflammatory response, and the oxidation-reduction process. Subsequently, a mouse model of pneumonia induced by <i>Pseudomonas aeruginosa</i> (<i"],"journal":["Frontiers in pharmacology"],"pagination":["587850"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8326761"],"repository":["biostudies-literature"],"pubmed_title":["Extract From <i>Tetrastigma hemsleyanum</i> Leaf Alleviates <i>Pseudomonas aeruginosa</i> Lung Infection: Network Pharmacology Analysis and Experimental Evidence."],"pmcid":["PMC8326761"],"pubmed_authors":["Ji T","Peng X","Ji WW","Li SM","Lou TL","Yuan LX","Shi QY","Zhang S","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Extract From <i>Tetrastigma hemsleyanum</i> Leaf Alleviates <i>Pseudomonas aeruginosa</i> Lung Infection: Network Pharmacology Analysis and Experimental Evidence.","description":"<i>Tetrastigma hemsleyanum</i> Diels & Gilg (<i>T. hemsleyanum</i>) has attracted much attention due to its ability on pneumonia, bronchitis, and immune-related diseases, while its functional components and underlying mechanism of action on pneumonia have not been fully elucidated. Herein, we used a systematic network pharmacology approach to explore the action mechanism of <i>T. hemsleyanum</i> leaf in the treatment of pneumonia. In this study, the results of network pharmacology demonstrated that there were 34 active components and 80 drug-disease targets in <i>T. hemsleyanum</i> leaf, which were strongly in connection with signal transduction, inflammatory response, and the oxidation-reduction process. Subsequently, a mouse model of pneumonia induced by <i>Pseudomonas aeruginosa</i> (<i","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-19T20:40:15.984Z","creation":"2022-02-11T02:56:03.973Z"},"accession":"S-EPMC8326761","cross_references":{"pubmed":["34349638"],"doi":["10.3389/fphar.2021.587850"]}}