biostudies-literatureUnknown12Lou TL<i>Tetrastigma hemsleyanum</i> Diels & Gilg (<i>T. hemsleyanum</i>) has attracted much attention due to its ability on pneumonia, bronchitis, and immune-related diseases, while its functional components and underlying mechanism of action on pneumonia have not been fully elucidated. Herein, we used a systematic network pharmacology approach to explore the action mechanism of <i>T. hemsleyanum</i> leaf in the treatment of pneumonia. In this study, the results of network pharmacology demonstrated that there were 34 active components and 80 drug-disease targets in <i>T. hemsleyanum</i> leaf, which were strongly in connection with signal transduction, inflammatory response, and the oxidation-reduction process. Subsequently, a mouse model of pneumonia induced by <i>Pseudomonas aeruginosa</i> (<iFrontiers in pharmacology587850https://www.ebi.ac.uk/biostudies/studies/S-EPMC8326761biostudies-literatureExtract From <i>Tetrastigma hemsleyanum</i> Leaf Alleviates <i>Pseudomonas aeruginosa</i> Lung Infection: Network Pharmacology Analysis and Experimental Evidence.PMC8326761Ji TPeng XJi WWLi SMLou TLYuan LXShi QYZhang SWang JfalseExtract From <i>Tetrastigma hemsleyanum</i> Leaf Alleviates <i>Pseudomonas aeruginosa</i> Lung Infection: Network Pharmacology Analysis and Experimental Evidence.<i>Tetrastigma hemsleyanum</i> Diels & Gilg (<i>T. hemsleyanum</i>) has attracted much attention due to its ability on pneumonia, bronchitis, and immune-related diseases, while its functional components and underlying mechanism of action on pneumonia have not been fully elucidated. Herein, we used a systematic network pharmacology approach to explore the action mechanism of <i>T. hemsleyanum</i> leaf in the treatment of pneumonia. In this study, the results of network pharmacology demonstrated that there were 34 active components and 80 drug-disease targets in <i>T. hemsleyanum</i> leaf, which were strongly in connection with signal transduction, inflammatory response, and the oxidation-reduction process. Subsequently, a mouse model of pneumonia induced by <i>Pseudomonas aeruginosa</i> (<i2021-01-01T00:00:00Z20212025-04-19T20:40:15.984Z2022-02-11T02:56:03.973ZS-EPMC83267613434963810.3389/fphar.2021.587850