biostudies-literatureUnknown12Heinrich I<b>Background:</b> Walking disability is one of the most frequent and burdening symptoms of progressive multiple sclerosis (MS). Most of the exercise intervention studies that showed an improvement in mobility performance were conducted in low to moderately disabled relapsing-remitting MS patients with interventions using the legs. However, MS patients with substantial walking disability hardly can perform these tasks. Earlier work has indicated that aerobic arm training might also improve walking performance and could therefore be a therapeutic option in already moderately disabled progressive MS patients. <b>Methods:</b> Patients with progressive MS and EDSS 4-6.5 were randomized using a computer-generated algorithm list to either a waitlist control group (CG) or an intervention group (IFrontiers in neurology644533https://www.ebi.ac.uk/biostudies/studies/S-EPMC8326796biostudies-literatureArm Ergometry to Improve Mobility in Progressive Multiple Sclerosis (AMBOS)-Results of a Pilot Randomized Controlled Trial.PMC8326796Rosenthal FStellmann JPHeesen CRamien CPatra SRosenkranz SCHeinrich IWelsch GHPottgen JGold SMSchulz KHVettorazzi EfalseArm Ergometry to Improve Mobility in Progressive Multiple Sclerosis (AMBOS)-Results of a Pilot Randomized Controlled Trial.<b>Background:</b> Walking disability is one of the most frequent and burdening symptoms of progressive multiple sclerosis (MS). Most of the exercise intervention studies that showed an improvement in mobility performance were conducted in low to moderately disabled relapsing-remitting MS patients with interventions using the legs. However, MS patients with substantial walking disability hardly can perform these tasks. Earlier work has indicated that aerobic arm training might also improve walking performance and could therefore be a therapeutic option in already moderately disabled progressive MS patients. <b>Methods:</b> Patients with progressive MS and EDSS 4-6.5 were randomized using a computer-generated algorithm list to either a waitlist control group (CG) or an intervention group (I2021-01-01T00:00:00Z20212026-05-09T04:48:29.112Z2022-02-11T04:24:23.253ZS-EPMC83267963434971610.3389/fneur.2021.644533