{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martin CN"],"funding":["NIBIB NIH HHS","National Science Foundation"],"pagination":["2686-2694"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8327477"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["56(8)"],"pubmed_abstract":["<h4>Objective</h4>To assess the association between commonly obtained endoscopic and serologic data and bronchoalveolar lavage pepsin assay (BAL) results in children with chronic cough.<h4>Study design</h4>We performed a retrospective chart review of 72 children with a BAL pepsin obtained through our Aerodigestive Center over an 18-month period. BAL outcomes include evidence of viral, bacterial, or fungal infection, presence of lipid-laden macrophages, and cytology (eosinophils, neutrophils, and lymphocytes). Gastrointestinal outcomes include esophagogastroduodenoscopy (EGD) and pH impedance probe findings. Other characteristics include serum eosinophils, neutrophils, and lymphocytes; spirometry; FeNO; and IgE.<h4>Results</h4>Seventy-two patients underwent BAL pepsin testing. Median age wa"],"journal":["Pediatric pulmonology"],"pubmed_title":["Positive bronchoalveolar lavage pepsin assay associated with viral and fungal respiratory infections in children with chronic cough."],"pmcid":["PMC8327477"],"funding_grant_id":["NIH 1U01EB021986","U01 EB021986"],"pubmed_authors":["Barnawi Z","Pillai D","Collins ME","Bauman NM","Gatti M","Krakovsky GM","Sehgal S","Pillai DK","Martin CN","Chorvinsky E"],"additional_accession":[]},"is_claimable":false,"name":"Positive bronchoalveolar lavage pepsin assay associated with viral and fungal respiratory infections in children with chronic cough.","description":"<h4>Objective</h4>To assess the association between commonly obtained endoscopic and serologic data and bronchoalveolar lavage pepsin assay (BAL) results in children with chronic cough.<h4>Study design</h4>We performed a retrospective chart review of 72 children with a BAL pepsin obtained through our Aerodigestive Center over an 18-month period. BAL outcomes include evidence of viral, bacterial, or fungal infection, presence of lipid-laden macrophages, and cytology (eosinophils, neutrophils, and lymphocytes). Gastrointestinal outcomes include esophagogastroduodenoscopy (EGD) and pH impedance probe findings. Other characteristics include serum eosinophils, neutrophils, and lymphocytes; spirometry; FeNO; and IgE.<h4>Results</h4>Seventy-two patients underwent BAL pepsin testing. Median age wa","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-04T01:23:55.474Z","creation":"2025-02-19T01:31:31.013Z"},"accession":"S-EPMC8327477","cross_references":{"pubmed":["33930245"],"doi":["10.1002/ppul.25450"]}}