biostudies-literatureMartin CNNIBIB NIH HHSNational Science Foundation2686-2694https://www.ebi.ac.uk/biostudies/studies/S-EPMC8327477biostudies-literatureUnknown56(8)<h4>Objective</h4>To assess the association between commonly obtained endoscopic and serologic data and bronchoalveolar lavage pepsin assay (BAL) results in children with chronic cough.<h4>Study design</h4>We performed a retrospective chart review of 72 children with a BAL pepsin obtained through our Aerodigestive Center over an 18-month period. BAL outcomes include evidence of viral, bacterial, or fungal infection, presence of lipid-laden macrophages, and cytology (eosinophils, neutrophils, and lymphocytes). Gastrointestinal outcomes include esophagogastroduodenoscopy (EGD) and pH impedance probe findings. Other characteristics include serum eosinophils, neutrophils, and lymphocytes; spirometry; FeNO; and IgE.<h4>Results</h4>Seventy-two patients underwent BAL pepsin testing. Median age waPediatric pulmonologyPositive bronchoalveolar lavage pepsin assay associated with viral and fungal respiratory infections in children with chronic cough.PMC8327477NIH 1U01EB021986U01 EB021986Barnawi ZPillai DCollins MEBauman NMGatti MKrakovsky GMSehgal SPillai DKMartin CNChorvinsky EfalsePositive bronchoalveolar lavage pepsin assay associated with viral and fungal respiratory infections in children with chronic cough.<h4>Objective</h4>To assess the association between commonly obtained endoscopic and serologic data and bronchoalveolar lavage pepsin assay (BAL) results in children with chronic cough.<h4>Study design</h4>We performed a retrospective chart review of 72 children with a BAL pepsin obtained through our Aerodigestive Center over an 18-month period. BAL outcomes include evidence of viral, bacterial, or fungal infection, presence of lipid-laden macrophages, and cytology (eosinophils, neutrophils, and lymphocytes). Gastrointestinal outcomes include esophagogastroduodenoscopy (EGD) and pH impedance probe findings. Other characteristics include serum eosinophils, neutrophils, and lymphocytes; spirometry; FeNO; and IgE.<h4>Results</h4>Seventy-two patients underwent BAL pepsin testing. Median age wa2021-01-01T00:00:00Z2021 Aug2025-04-04T01:23:55.474Z2025-02-19T01:31:31.013ZS-EPMC83274773393024510.1002/ppul.25450