{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Terraf P"],"funding":["NCI NIH HHS"],"pagination":["a006089"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8327883"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(4)"],"pubmed_abstract":["Comprehensive characterization of somatic genomic alterations has led to fundamental shifts in our understanding of tumor biology. In clinical practice, these studies can lead to modifications of diagnosis and/or specific treatment implications, fulfilling the promise of personalized medicine. Herein, we describe a 78-yr-old woman under surveillance for long-standing untreated chronic lymphocytic leukemia (CLL). Molecular studies from a peripheral blood specimen revealed a <i>TP53</i> p.V157F mutation, whereas karyotype and fluorescence in situ hybridization (FISH) identified a 17p deletion, trisomy 12, and no evidence of <i>IGH-CCND1</i> rearrangement. Positron emission tomography-computed tomography scan identified multistation intra-abdominal lymphadenopathy and a pulmonary nodule, and "],"journal":["Cold Spring Harbor molecular case studies"],"pubmed_title":["Twists and turns from \"tumor in tumor\" profiling: surveillance of chronic lymphocytic leukemia (CLL) leads to detection of a lung adenocarcinoma, whose genomic characterization alters the original hematologic diagnosis."],"pmcid":["PMC8327883"],"funding_grant_id":["P30 CA008748"],"pubmed_authors":["Sholl LM","Terraf P","MacConaill LE","Kim A","Lindeman NI","Hwang DH","Davids MS","Stachler M","Dal Cin P","Awad MM","Garcia EP","Dubuc AM"],"additional_accession":[]},"is_claimable":false,"name":"Twists and turns from \"tumor in tumor\" profiling: surveillance of chronic lymphocytic leukemia (CLL) leads to detection of a lung adenocarcinoma, whose genomic characterization alters the original hematologic diagnosis.","description":"Comprehensive characterization of somatic genomic alterations has led to fundamental shifts in our understanding of tumor biology. In clinical practice, these studies can lead to modifications of diagnosis and/or specific treatment implications, fulfilling the promise of personalized medicine. Herein, we describe a 78-yr-old woman under surveillance for long-standing untreated chronic lymphocytic leukemia (CLL). Molecular studies from a peripheral blood specimen revealed a <i>TP53</i> p.V157F mutation, whereas karyotype and fluorescence in situ hybridization (FISH) identified a 17p deletion, trisomy 12, and no evidence of <i>IGH-CCND1</i> rearrangement. Positron emission tomography-computed tomography scan identified multistation intra-abdominal lymphadenopathy and a pulmonary nodule, and ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2026-03-15T11:15:48.976Z","creation":"2025-06-01T01:33:11.271Z"},"accession":"S-EPMC8327883","cross_references":{"pubmed":["34074652"],"doi":["10.1101/mcs.a006089"]}}