{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nagai H"],"funding":["Intramural NIH HHS","Japanese Society for the Promotion of Science"],"pagination":["3888-3895"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8328498"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["60(8)"],"pubmed_abstract":["Objectives
Elevation of serum IL-18 in adult-onset Still's disease (AOSD) and systemic JIA (sJIA) suggests the role of the inflammasome in these diseases. Gasdermin D is a pore-forming protein playing central roles in inflammasome-mediated inflammation, but its role in rheumatic disease is unknown. We aimed to elucidate the auto-inflammatory mechanisms in AOSD and sJIA.Methods
Patients with AOSD, sJIA, hemophagocytic lymphohistiocytosis (HLH) and Behçet's disease followed at Yokohama City University (YCU), or US National Institutes of Health (NIH) were included in the study. Disease activity was evaluated by the modified Pouchot score. Ferritin and N-terminal gasdermin D levels in serum and culture supernatant were measured by ELISA. Primary monocytes (Mo) were stimulated w"],"journal":["Rheumatology (Oxford, England)"],"pubmed_title":["Elevated serum gasdermin D N-terminal implicates monocyte and macrophage pyroptosis in adult-onset Still's disease."],"pmcid":["PMC8328498"],"funding_grant_id":["ZIA AR041198","Grants-in-Aid for Scientific Research #15K15374 (Y.K.) and NIH grant # Z01-AR-041198 (M.J.O.)"],"pubmed_authors":["Yoshimi R","Nagai H","Nakajima H","Kunishita Y","Szymanski AM","Ombrello MJ","Henmi R","Kirino Y","Nakano H"],"additional_accession":[]},"is_claimable":false,"name":"Elevated serum gasdermin D N-terminal implicates monocyte and macrophage pyroptosis in adult-onset Still's disease.","description":"Objectives
Elevation of serum IL-18 in adult-onset Still's disease (AOSD) and systemic JIA (sJIA) suggests the role of the inflammasome in these diseases. Gasdermin D is a pore-forming protein playing central roles in inflammasome-mediated inflammation, but its role in rheumatic disease is unknown. We aimed to elucidate the auto-inflammatory mechanisms in AOSD and sJIA.Methods
Patients with AOSD, sJIA, hemophagocytic lymphohistiocytosis (HLH) and Behçet's disease followed at Yokohama City University (YCU), or US National Institutes of Health (NIH) were included in the study. Disease activity was evaluated by the modified Pouchot score. Ferritin and N-terminal gasdermin D levels in serum and culture supernatant were measured by ELISA. Primary monocytes (Mo) were stimulated w","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-04T23:33:53.921Z","creation":"2025-04-04T23:33:53.921Z"},"accession":"S-EPMC8328498","cross_references":{"pubmed":["33550379"],"doi":["10.1093/rheumatology/keaa814"]}}