{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Roos CR"],"funding":["National Institute on Alcohol Abuse and Alcoholism","NCATS NIH HHS","NCCIH NIH HHS","NIDA NIH HHS","National Center for Complementary and Integrative Health","NIAAA NIH HHS","National Institute on Drug Abuse"],"pagination":["2360-2371"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8328878"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["116(9)"],"pubmed_abstract":["<h4>Aims</h4>Theory-driven, exploratory study to: (i) identify a reward drinking phenotype in young adults; (ii) evaluate this phenotype as a predictor of naltrexone response; and (iii) examine mechanisms of naltrexone in reward drinkers.<h4>Design</h4>Secondary analysis of a randomized controlled trial.<h4>Setting</h4>USA.<h4>Participants</h4>A total of 128 young adult (ages 18-25) heavy drinkers.<h4>Interventions</h4>Naltrexone versus placebo.<h4>Measurements</h4>Daily surveys assessed affect, urge, drinking, and context. The Drinking Motives Questionnaire was used to identify phenotypes based on reward (enhancement motives) and relief (coping motives) drinking.<h4>Findings</h4>We identified three profiles: \"Low reward/Low relief\" (14.1%; low enhancement/low coping motives); \"Reward drin"],"journal":["Addiction (Abingdon, England)"],"pubmed_title":["Reward drinking and naltrexone treatment response among young adult heavy drinkers."],"pmcid":["PMC8328878"],"funding_grant_id":["T32 DA007238","R34AA026021","K23AT011342","K23 AT011342","R21 AA026918","U24AA022002","U24 AA022002","T32DA007238‐27","UL1 TR001863","K12 DA000167","R34 AA026021","UH3AA026214","K12DA000167"],"pubmed_authors":["Leeman RF","Mann K","Bold KW","Witkiewitz K","Roos CR","DeMartini KS","Fucito LM","Corbin WR","Kranzler HR","O'Malley SS"],"additional_accession":[]},"is_claimable":false,"name":"Reward drinking and naltrexone treatment response among young adult heavy drinkers.","description":"<h4>Aims</h4>Theory-driven, exploratory study to: (i) identify a reward drinking phenotype in young adults; (ii) evaluate this phenotype as a predictor of naltrexone response; and (iii) examine mechanisms of naltrexone in reward drinkers.<h4>Design</h4>Secondary analysis of a randomized controlled trial.<h4>Setting</h4>USA.<h4>Participants</h4>A total of 128 young adult (ages 18-25) heavy drinkers.<h4>Interventions</h4>Naltrexone versus placebo.<h4>Measurements</h4>Daily surveys assessed affect, urge, drinking, and context. The Drinking Motives Questionnaire was used to identify phenotypes based on reward (enhancement motives) and relief (coping motives) drinking.<h4>Findings</h4>We identified three profiles: \"Low reward/Low relief\" (14.1%; low enhancement/low coping motives); \"Reward drin","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-04T10:44:13.123Z","creation":"2025-04-04T10:44:13.123Z"},"accession":"S-EPMC8328878","cross_references":{"pubmed":["33620746"],"doi":["10.1111/add.15453"]}}