{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gao S"],"funding":["U.S. Department of Health &amp; Human Services | NIH | National Institute of Dental and Craniofacial Research","NIDCR NIH HHS","National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund","NIGMS NIH HHS"],"pagination":["433-444"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8329259"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["125(3)"],"pubmed_abstract":["<h4>Background</h4>The effect of Porphyromonas gingivalis (Pg) infection on oesophageal squamous cell carcinoma (ESCC) prognosis, chemotherapeutic efficacy, and oesophageal cancer cell apoptosis resistance and proliferation remain poorly understood.<h4>Methods</h4>Clinicopathological data from 312 ESCC oesophagectomy patients, along with the computed tomography imaging results and longitudinal cancerous tissue samples from a patient subset (n = 85) who received neoadjuvant chemotherapy (NACT), were analysed. Comparison of overall survival and response rate to NACT between Pg-infected and Pg-uninfected patients was made by multivariate Cox analysis and Response Evaluation Criteria in Solid Tumours v.1.1 criteria. The influence of Pg on cell proliferation and drug-induced apoptosis was examined in ESCC patients and validated in vitro and in vivo.<h4>Results</h4>The 5-year overall survival was lower in Pg-positive patients, and infection was associated with multiple clinicopathological factors and pathologic tumour, node, metastasis stage. Of the 85 patients who received NACT, Pg infection was associated with a lower response rate and 5-year overall survival. Infection with Pg resulted in apoptosis resistance in ESCC and promoted ESCC cell viability, which was confirmed in longitudinal cancerous tissue samples. Pg-induced apoptosis resistance was dependent on fimbriae and STAT3.<h4>Conclusions</h4>Pg infection is associated with a worse ESCC prognosis, reduced chemotherapy efficacy, and can potentiate the aggressive behaviour of ESCC cells."],"journal":["British journal of cancer"],"pubmed_title":["Porphyromonas gingivalis infection exacerbates oesophageal cancer and promotes resistance to neoadjuvant chemotherapy."],"pmcid":["PMC8329259"],"funding_grant_id":["R01 DE026727","R01 DE026963","DE 026Lamont727","P20 GM125504","GS 81472234","DE 0Lamont26727","DE 026727"],"pubmed_authors":["Liang S","Liu K","Li J","Gu Z","Wang H","Lamont RJ","Mohammed M","Liu Y","Yakoumatos L","Lu L","Scott DA","Ren J","Zhou F","Yuan X","Gao S","Duan X"],"additional_accession":[]},"is_claimable":false,"name":"Porphyromonas gingivalis infection exacerbates oesophageal cancer and promotes resistance to neoadjuvant chemotherapy.","description":"<h4>Background</h4>The effect of Porphyromonas gingivalis (Pg) infection on oesophageal squamous cell carcinoma (ESCC) prognosis, chemotherapeutic efficacy, and oesophageal cancer cell apoptosis resistance and proliferation remain poorly understood.<h4>Methods</h4>Clinicopathological data from 312 ESCC oesophagectomy patients, along with the computed tomography imaging results and longitudinal cancerous tissue samples from a patient subset (n = 85) who received neoadjuvant chemotherapy (NACT), were analysed. Comparison of overall survival and response rate to NACT between Pg-infected and Pg-uninfected patients was made by multivariate Cox analysis and Response Evaluation Criteria in Solid Tumours v.1.1 criteria. The influence of Pg on cell proliferation and drug-induced apoptosis was examined in ESCC patients and validated in vitro and in vivo.<h4>Results</h4>The 5-year overall survival was lower in Pg-positive patients, and infection was associated with multiple clinicopathological factors and pathologic tumour, node, metastasis stage. Of the 85 patients who received NACT, Pg infection was associated with a lower response rate and 5-year overall survival. Infection with Pg resulted in apoptosis resistance in ESCC and promoted ESCC cell viability, which was confirmed in longitudinal cancerous tissue samples. Pg-induced apoptosis resistance was dependent on fimbriae and STAT3.<h4>Conclusions</h4>Pg infection is associated with a worse ESCC prognosis, reduced chemotherapy efficacy, and can potentiate the aggressive behaviour of ESCC cells.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-05T10:04:06.629Z","creation":"2025-04-05T10:04:06.629Z"},"accession":"S-EPMC8329259","cross_references":{"pubmed":["33981017"],"doi":["10.1038/s41416-021-01419-5"]}}