{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(5)"],"submitter":["Ramm R"],"funding":["German Research Foundation","Deutsche Herzstiftung e. V."],"pubmed_abstract":["Decellularization of xenogeneic heart valves might lead to excellent regenerative implants, from which many patients could benefit. However, this material carries various xenogeneic epitopes and thus bears a considerable inherent immunological risk. Here, we investigated the regenerative and immunogenic potential of xenogeneic decellularized heart valve implants using pigs deficient for the galactosyltransferase gene (GGTA1-KO) as novel large animal model. Decellularized aortic and pulmonary heart valves obtained from sheep, wild-type pigs or GGTA1-KO pigs were implanted into GGTA1-KO pigs for 3, or 6 months, respectively. Explants were analyzed histologically, immunhistologically (CD3, CD21 and CD172a) and anti-αGal antibody serum titers were determined by ELISA. Xenogeneic sheep derived "],"journal":["Regenerative biomaterials"],"pagination":["rbab036"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8329474"],"repository":["biostudies-literature"],"pubmed_title":["Immunological and functional features of decellularized xenogeneic heart valves after transplantation into GGTA1-KO pigs."],"pmcid":["PMC8329474"],"pubmed_authors":["Kohler P","Tudorache I","Ciubotaru A","Petersen B","Hoffler K","Goecke T","Haverich A","Bothe F","Niemann H","Ramm R","Sarikouch S","Cebotari S","Hilfiker A"],"additional_accession":[]},"is_claimable":false,"name":"Immunological and functional features of decellularized xenogeneic heart valves after transplantation into GGTA1-KO pigs.","description":"Decellularization of xenogeneic heart valves might lead to excellent regenerative implants, from which many patients could benefit. However, this material carries various xenogeneic epitopes and thus bears a considerable inherent immunological risk. Here, we investigated the regenerative and immunogenic potential of xenogeneic decellularized heart valve implants using pigs deficient for the galactosyltransferase gene (GGTA1-KO) as novel large animal model. Decellularized aortic and pulmonary heart valves obtained from sheep, wild-type pigs or GGTA1-KO pigs were implanted into GGTA1-KO pigs for 3, or 6 months, respectively. Explants were analyzed histologically, immunhistologically (CD3, CD21 and CD172a) and anti-αGal antibody serum titers were determined by ELISA. Xenogeneic sheep derived ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-06-01T03:29:35.083Z","creation":"2024-11-15T21:38:02.711Z"},"accession":"S-EPMC8329474","cross_references":{"pubmed":["35928180"],"doi":["10.1093/rb/rbab036"]}}