{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["78(9)"],"submitter":["Almeida OP"],"pubmed_abstract":["<h4>Importance</h4>One in 3 adults experiences clinically significant symptoms of depression during the first year after a stroke, but evidence to support the use of antidepressants in this population remains scant.<h4>Objective</h4>To investigate whether daily treatment with 20 mg of fluoxetine hydrochloride reduces the proportion of people affected by clinically significant symptoms of depression after stroke.<h4>Design, setting, and participants</h4>In this secondary analysis of the Assessment of Fluoxetine in Stroke Recovery parallel-group, randomized (1:1 assignment), double-blind, placebo-controlled clinical trial, 1221 participants in Australia, New Zealand, and Vietnam were recruited between January 11, 2013, and June 30, 2019, and were followed up for 6 months. Adults aged 18 year"],"journal":["JAMA neurology"],"pagination":["1072-1079"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8329781"],"repository":["biostudies-literature"],"pubmed_title":["Depression Outcomes Among Patients Treated With Fluoxetine for Stroke Recovery: The AFFINITY Randomized Clinical Trial."],"pmcid":["PMC8329781"],"pubmed_authors":["Abraham A","Le TH","Le TD","Carr M","Williams C","Do CM","Bailey A","Hoang HV","Le ST","Donnan GA","Taylor C","Nguyen YH","Hankey GJ","Gopinath S","Spooner M","Anderson CS","Ramirez D","Nguyen HN","Walker S","Jan S","Patel V","Duckett E","Nguyen HT","Ratcliffe M","Sahathevan R","Phan HT","Le TV","Levy S","Delcourt C","Low E","Assessment of Fluoxetine in Stroke Recovery (AFFINITY) Trial Collaboration","Thach KN","Tran GK","Hourn M","White J","Malavera A","Massey J","Jones B","Stockle P","Nguyen GT","Lopez M","Lam NT","Trewin B","O'Rourke F","Le QN","Duroux M","Macdonald B","Sanctuary C","Burdusel C","Nguyen HB","Hartwell T","Mead GE","Gawarikar Y","Vuong TX","Mughal N","Ha OK","Abeysuriya K","Le BV","Hoang UT","Do PT","Calic Z","Mccormack S","Almeida OP","Shandiz EE","Maxwell V","Hickey K","Dunne J","Kho L","Faux S","Edmonds G","Dennis MS","McCoy R","Latif M","Drummond C","Pepperell B","Lung T","Murray V","Huynh HQ","Davis S","Christley J","Truong PT","Nguyen VT","Carter G","Murray A","Davenport C","Vu LT","Ngo ND","Lundstrom E","Broughton P","McDonald A","Dang HH","Nguyen DT","Evans A","Sangvatanakul F","McNaughton H","Dao NT","Li Q","Lindley RI","Daines M","Wong LK","Trinh PT","Bolitho S","Chen C","Bergqvist J","Dang HC","Le HT","McQueen R","Ghia D","Boyle K","Veitch K","Lu HN","Dinh LV","Masterson A","Jude M","Nguyen TB","Southwell L","Robertson R","Nguyen TD","Cheuk G","Nguyen CV","Mohr K","Nguyen TH","Vo LN","Surendran V","Le VC","Coyle H","Hayes H","Boudville A","O'Loughlin N","Tabesh M","Nguyen TA","Kuang YM","Cappelen-Smith C","Rigney L","Liu Y","Nguyen TT","O'Dea J","Nguyen TV","Katrak P","Jackson D","Tsoleridis J","Hewitt L","Nguyen BT","Ewing M","Redpath C","Celestino S","Nguyen SH","Dao PV","Tran TT","Tran TV","Granger A","Han HT","Leung Q","Tran TN","Dinh NN","Nguyen SV","Vallat W","Do Nguyen D","Chalissery J","Pollack M","Le LC","Truong LV","Hackett M","Deane L","Nguyen AN","Page K","Blacker D","Le KK","Akbari S","Ray E","Kieu DV","Flicker L","Pham TH","Wheelwright D","Wijeratne T","Moey A","Markus R","Nham B","Zagami A","Lanford J","Dang TN","Pham TT","Baldwin C","Dinh HH","Siracusa E","Le LM","Mai HV","Kleinig T","Mahawish K","Peterson S","Mai YB","Bui TC","Rollason M","Pham CV","Askar S","Kernaghan L","Dinh HT","Doan BT","Oakley K","Day S","Fu V","Dam AH","Nguyen PD","Lee L","Truong NQ","Pham SP","Shivlal D","Yi Q","Pepper E","Ngo HT","Priglinger M","Kieu TV","Tang M","Lee A","Dao KD","Dang TH","Cheng Q","Geraghty R","Nathani D","Pham BN","Bates TR","DeCaigney S","Withanage A","Lallu B","Ruddell K","Herbert R","Tran PH","Pham AG","McLennan C","Roberts C","Choong H","Knight K","Silver G","Brown A","Winker A","Cordato D","Withiel T","O'Neill M","Rees M","Nguyen -B","Nguyen MT","Pham QN","Burnet H","Dinh TQ","Kumar R","Vu TT","Le OT","Billot L","Duque V","Tran HT","Luong DH","Nguyen NH","Field D","Ormond S","Pham QB","Le N","Shone S","Tan BL","Nguyen LT","Nguyen LV","Baines H","Whittaker KA","Claxton A","Phua C","Dam LC","Wu A","Tong TM","Bompoint S","McDougall AJ","Tarrant L","Duong CD","Khuong DQ","Nguyen MH","Do VP","Hair C","Huynh NX","Etherton-Beer C","Bui TN","Kunchok A","Gommans J","Vo TV","Schmid D","New P","Tan AL","Mamun A","Nagesh K","Krause M","Barrett S","Mai TD","Bunce L","Ngo TK","Thai H","Nguyen LH","Ngo TB","Tran LK","Laubscher S","Carcel C","Le NT","Chua C","Le LTM","Do CQ","Ford A","Hong UH","Morgan P","Le NH"],"additional_accession":[]},"is_claimable":false,"name":"Depression Outcomes Among Patients Treated With Fluoxetine for Stroke Recovery: The AFFINITY Randomized Clinical Trial.","description":"<h4>Importance</h4>One in 3 adults experiences clinically significant symptoms of depression during the first year after a stroke, but evidence to support the use of antidepressants in this population remains scant.<h4>Objective</h4>To investigate whether daily treatment with 20 mg of fluoxetine hydrochloride reduces the proportion of people affected by clinically significant symptoms of depression after stroke.<h4>Design, setting, and participants</h4>In this secondary analysis of the Assessment of Fluoxetine in Stroke Recovery parallel-group, randomized (1:1 assignment), double-blind, placebo-controlled clinical trial, 1221 participants in Australia, New Zealand, and Vietnam were recruited between January 11, 2013, and June 30, 2019, and were followed up for 6 months. Adults aged 18 year","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-04T09:37:32.881Z","creation":"2025-04-04T09:37:32.881Z"},"accession":"S-EPMC8329781","cross_references":{"pubmed":["34338714"],"doi":["10.1001/jamaneurol.2021.2418"]}}