{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang BL"],"funding":["Shanghai Municipal Health Commission","Shanghai Pudong Hospital key Discipline in Nephrology","Shanghai Pudong Hospital project"],"pagination":["2095-2109"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8329951"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(8)"],"pubmed_abstract":["Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. However, because of shared complications between DKD and chronic kidney disease (CKD), the description and characterization of DKD remain ambiguous in the clinic, hindering the diagnosis and treatment of early-stage DKD patients. Although estimated glomerular filtration rate and albuminuria are well-established biomarkers of DKD, early-stage DKD is rarely accompanied by a high estimated glomerular filtration rate, and thus there is a need for new sensitive biomarkers. Transcriptome profiling of kidney tissue has been reported previously, although RNA sequencing (RNA-Seq) analysis of the venous blood platelets in DKD patients has not yet been described. In the present study, we performed RNA-Seq analysis of venou"],"journal":["FEBS open bio"],"pubmed_title":["Identification of differentially expressed genes in diabetic kidney disease by RNA-Seq analysis of venous blood platelets."],"pmcid":["PMC8329951"],"funding_grant_id":["Zdxk2020-10","201840025","YJ2020-04"],"pubmed_authors":["Yang XH","Jin HM","Zhang BL","Zhan XL"],"additional_accession":[]},"is_claimable":false,"name":"Identification of differentially expressed genes in diabetic kidney disease by RNA-Seq analysis of venous blood platelets.","description":"Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. However, because of shared complications between DKD and chronic kidney disease (CKD), the description and characterization of DKD remain ambiguous in the clinic, hindering the diagnosis and treatment of early-stage DKD patients. Although estimated glomerular filtration rate and albuminuria are well-established biomarkers of DKD, early-stage DKD is rarely accompanied by a high estimated glomerular filtration rate, and thus there is a need for new sensitive biomarkers. Transcriptome profiling of kidney tissue has been reported previously, although RNA sequencing (RNA-Seq) analysis of the venous blood platelets in DKD patients has not yet been described. In the present study, we performed RNA-Seq analysis of venou","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-26T00:49:03.184Z","creation":"2022-02-11T05:51:38.71Z"},"accession":"S-EPMC8329951","cross_references":{"pubmed":["34029013"],"doi":["10.1002/2211-5463.13199"]}}