biostudies-literatureRibeiro Guerra MLigue Contre le Cancerthe comprehensive cancer center SiRICBrazilian National Council for the Improvement of Higher Education - CAPESInstitut National Du CancerBrazilian National Council for the Improvement of Higher Education – CAPES79https://www.ebi.ac.uk/biostudies/studies/S-EPMC8336294biostudies-literatureUnknown23(1)<h4>Background</h4>Diagnostic ionizing radiation is a risk factor for breast cancer (BC). BC risk increases with increased dose to the chest and decreases with increased age at exposure, with possible effect modification related to familial or genetic predisposition. While chest X-rays increase the BC risk of BRCA1/2 mutation carriers compared to non-carriers, little is known for women with a hereditary predisposition to BC but who tested negative for a BRCA1 or BRCA2 (BRCA1/2) mutation.<h4>Methods</h4>We evaluated the effect of chest X-rays from diagnostic medical procedures in a dataset composed of 1552 BC cases identified through French family cancer clinics and 1363 unrelated controls. Participants reported their history of X-ray exposures in a detailed questionnaire and were tested foBreast cancer research : BCRDiagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation.PMC8336294BEX 5852/15-3INCa-DGOS-4654PRE11/NAPRE05/DSLb2008-029/LL-LCPRE07/DSLBignon YJCavaciuti ELesueur FLasset CPujol PAudebert-Bellanger SLejeune-Dumoulin SSoubrier FMaugard CMBonadona VCoignard JGladieff LAndrieu NDreyfus HFert-Ferrer SBerthet PDelnatte CGesta PTardivon AChiesa JNogues CMazoyer SCaron OFloquet AGiraud SRibeiro Guerra MFaivre LLongy MDondon MGLortholary ABeauvallet JMortemousque IFajac AFrebourg TLe Gal DVenat-Bouvet LMebirouk NFricker JPLuporsi ECoupier ITinat JEisinger FAdenis-Lavignasse CBelotti MBarjhoux LDamiola FEon-Marchais SStoppa-Lyonnet DBuecher BLimacher JMColas CGauthier-Villars MfalseDiagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation.<h4>Background</h4>Diagnostic ionizing radiation is a risk factor for breast cancer (BC). BC risk increases with increased dose to the chest and decreases with increased age at exposure, with possible effect modification related to familial or genetic predisposition. While chest X-rays increase the BC risk of BRCA1/2 mutation carriers compared to non-carriers, little is known for women with a hereditary predisposition to BC but who tested negative for a BRCA1 or BRCA2 (BRCA1/2) mutation.<h4>Methods</h4>We evaluated the effect of chest X-rays from diagnostic medical procedures in a dataset composed of 1552 BC cases identified through French family cancer clinics and 1363 unrelated controls. Participants reported their history of X-ray exposures in a detailed questionnaire and were tested fo2021-01-01T00:00:00Z2021 Aug2025-04-19T00:30:01.467Z2022-02-11T04:14:50.229ZS-EPMC83362943434442610.1186/s13058-021-01456-1