{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van der Heide DM"],"funding":["NCI NIH HHS","National Institutes of Health"],"pagination":["104-112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8338754"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["266"],"pubmed_abstract":["<h4>Background</h4>Young adults with metastatic colorectal cancer (mCRC) may have higher rates of deficient mismatch repair (dMMR) than older patients. This study sought to assess patterns of MMR-testing and survival among young adult mCRC patients in the National Cancer Database (NCDB), hypothesizing that dMMR correlates with worse survival than in MMR-proficient (pMMR) patients.<h4>Methods</h4>Stage-IV colorectal cancers were identified in NCDB (2010-2016). Demographic and clinical features were compared between younger (age ≤ 30) and older mCRC patients and tested for association with overall survival. Stage-IV disease without other recorded metastatic sites defined peritoneal metastasis (PM). Fisher-exact tests compared proportions and Cox models tested association with overall surviva"],"journal":["The Journal of surgical research"],"pubmed_title":["Mismatch Repair Status Correlates with Survival in Young Adults with Metastatic Colorectal Cancer."],"pmcid":["PMC8338754"],"funding_grant_id":["T32#CA148062","T32 CA078586","T32 CA148062","T32#CA078586","P01 CA217797"],"pubmed_authors":["Sherman SK","Turaga KK","Chan CHF","van der Heide DM"],"additional_accession":[]},"is_claimable":false,"name":"Mismatch Repair Status Correlates with Survival in Young Adults with Metastatic Colorectal Cancer.","description":"<h4>Background</h4>Young adults with metastatic colorectal cancer (mCRC) may have higher rates of deficient mismatch repair (dMMR) than older patients. This study sought to assess patterns of MMR-testing and survival among young adult mCRC patients in the National Cancer Database (NCDB), hypothesizing that dMMR correlates with worse survival than in MMR-proficient (pMMR) patients.<h4>Methods</h4>Stage-IV colorectal cancers were identified in NCDB (2010-2016). Demographic and clinical features were compared between younger (age ≤ 30) and older mCRC patients and tested for association with overall survival. Stage-IV disease without other recorded metastatic sites defined peritoneal metastasis (PM). Fisher-exact tests compared proportions and Cox models tested association with overall surviva","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-18T16:16:21.323Z","creation":"2025-04-07T03:18:50.453Z"},"accession":"S-EPMC8338754","cross_references":{"pubmed":["33989889"],"doi":["10.1016/j.jss.2021.03.040"]}}