{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Skov-Jeppesen K"],"funding":["AP Møller Fonden","NIDDK NIH HHS","Foundation for the National Institutes of Health","Novo Nordisk Foundation Center for Basic Metabolic Research","Novo Nordisk Fonden"],"pagination":["1448-1458"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8338760"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(8)"],"pubmed_abstract":["Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted postprandially. In healthy humans, both hormones decrease bone resorption accompanied by a rapid reduction in parathyroid hormone (PTH). The aim of this study was to investigate whether the changes in bone turnover after meal intake and after GIP- and GLP-2 injections, respectively, are mediated via a reduction in PTH secretion. This was tested in female patients with hypoparathyroidism given a standardized liquid mixed-meal test (n = 7) followed by a peptide injection test (n = 4) using a randomized crossover design. We observed that the meal- and GIP- but not the GLP-2-induced changes in bone turnover markers were preserved in the patients with hypoparathyroidism. To understan"],"journal":["Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research"],"pubmed_title":["The Antiresorptive Effect of GIP, But Not GLP-2, Is Preserved in Patients With Hypoparathyroidism-A Randomized Crossover Study."],"pmcid":["PMC8338760"],"funding_grant_id":["1R01DK088188‐01","NNF18OC0052699","R01 DK088188","NNF19OC0055047","NNF18CC0034900","1R01DK088188-01"],"pubmed_authors":["Hansen MS","Jafari A","Holst JJ","Hartmann B","Oeke J","Hepp N","Olson JA","Balenga N","Svane MS","Madsbad S","Rosenkilde MM","Skov-Jeppesen K","Kassem M","Frost M","Beck Jensen JE"],"additional_accession":[]},"is_claimable":false,"name":"The Antiresorptive Effect of GIP, But Not GLP-2, Is Preserved in Patients With Hypoparathyroidism-A Randomized Crossover Study.","description":"Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted postprandially. In healthy humans, both hormones decrease bone resorption accompanied by a rapid reduction in parathyroid hormone (PTH). The aim of this study was to investigate whether the changes in bone turnover after meal intake and after GIP- and GLP-2 injections, respectively, are mediated via a reduction in PTH secretion. This was tested in female patients with hypoparathyroidism given a standardized liquid mixed-meal test (n = 7) followed by a peptide injection test (n = 4) using a randomized crossover design. We observed that the meal- and GIP- but not the GLP-2-induced changes in bone turnover markers were preserved in the patients with hypoparathyroidism. To understan","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2026-05-07T21:27:23.945Z","creation":"2022-02-11T11:27:55.565Z"},"accession":"S-EPMC8338760","cross_references":{"pubmed":["33852173"],"doi":["10.1002/jbmr.4308"]}}