biostudies-literatureSkov-Jeppesen KAP Møller FondenNIDDK NIH HHSFoundation for the National Institutes of HealthNovo Nordisk Foundation Center for Basic Metabolic ResearchNovo Nordisk Fonden1448-1458https://www.ebi.ac.uk/biostudies/studies/S-EPMC8338760biostudies-literatureUnknown36(8)Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted postprandially. In healthy humans, both hormones decrease bone resorption accompanied by a rapid reduction in parathyroid hormone (PTH). The aim of this study was to investigate whether the changes in bone turnover after meal intake and after GIP- and GLP-2 injections, respectively, are mediated via a reduction in PTH secretion. This was tested in female patients with hypoparathyroidism given a standardized liquid mixed-meal test (n = 7) followed by a peptide injection test (n = 4) using a randomized crossover design. We observed that the meal- and GIP- but not the GLP-2-induced changes in bone turnover markers were preserved in the patients with hypoparathyroidism. To understanJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchThe Antiresorptive Effect of GIP, But Not GLP-2, Is Preserved in Patients With Hypoparathyroidism-A Randomized Crossover Study.PMC83387601R01DK088188‐01NNF18OC0052699R01 DK088188NNF19OC0055047NNF18CC00349001R01DK088188-01Hansen MSJafari AHolst JJHartmann BOeke JHepp NOlson JABalenga NSvane MSMadsbad SRosenkilde MMSkov-Jeppesen KKassem MFrost MBeck Jensen JEfalseThe Antiresorptive Effect of GIP, But Not GLP-2, Is Preserved in Patients With Hypoparathyroidism-A Randomized Crossover Study.Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted postprandially. In healthy humans, both hormones decrease bone resorption accompanied by a rapid reduction in parathyroid hormone (PTH). The aim of this study was to investigate whether the changes in bone turnover after meal intake and after GIP- and GLP-2 injections, respectively, are mediated via a reduction in PTH secretion. This was tested in female patients with hypoparathyroidism given a standardized liquid mixed-meal test (n = 7) followed by a peptide injection test (n = 4) using a randomized crossover design. We observed that the meal- and GIP- but not the GLP-2-induced changes in bone turnover markers were preserved in the patients with hypoparathyroidism. To understan2021-01-01T00:00:00Z2021 Aug2026-05-07T21:27:23.945Z2022-02-11T11:27:55.565ZS-EPMC83387603385217310.1002/jbmr.4308