{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tao T"],"funding":["Training Plan of Excellent Young Medical Talents in Shanghai"],"pagination":["6650329"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8339895"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2021"],"pubmed_abstract":["<h4>Background</h4>B7 family members and ligands have been identified as critical checkpoints in orchestrating the immune response during sepsis. V-domain Ig suppressor of T cell activation (VISTA) is a new inhibitory immune checkpoint involved in restraining T cell response. Previous studies demonstrated that VISTA engagement on T cells and myeloid cells could transmit inhibitory signals, resulting in reduced activation and function. The current study was designed to determine the potential therapeutic effects of a high-affinity anti-VISTA antibody (clone MH5A) in a murine model of sepsis.<h4>Methods</h4>Polymicrobial sepsis was induced in male C57BL/6 mice via cecal ligation and puncture. Expression profiles of VISTA on T lymphocytes and macrophage were examined at 24 and 72 h postsurger"],"journal":["Mediators of inflammation"],"pubmed_title":["High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response."],"pmcid":["PMC8339895"],"funding_grant_id":["81701964","81772105","2017YQ015","81671887","19QA1408500"],"pubmed_authors":["Zhang G","Ma Q","Shi L","Li T","Bo L","Zhang H","Ye B","Tao T","Deng X","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"High-Affinity Anti-VISTA Antibody Protects against Sepsis by Inhibition of T Lymphocyte Apoptosis and Suppression of the Inflammatory Response.","description":"<h4>Background</h4>B7 family members and ligands have been identified as critical checkpoints in orchestrating the immune response during sepsis. V-domain Ig suppressor of T cell activation (VISTA) is a new inhibitory immune checkpoint involved in restraining T cell response. Previous studies demonstrated that VISTA engagement on T cells and myeloid cells could transmit inhibitory signals, resulting in reduced activation and function. The current study was designed to determine the potential therapeutic effects of a high-affinity anti-VISTA antibody (clone MH5A) in a murine model of sepsis.<h4>Methods</h4>Polymicrobial sepsis was induced in male C57BL/6 mice via cecal ligation and puncture. Expression profiles of VISTA on T lymphocytes and macrophage were examined at 24 and 72 h postsurger","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-05T15:09:54.257Z","creation":"2022-02-11T05:15:05.258Z"},"accession":"S-EPMC8339895","cross_references":{"pubmed":["34366711"],"doi":["10.1155/2021/6650329"]}}