biostudies-literatureUnknown6(8)Melsom TNorthern Norway Regional Health Authority<h4>Introduction</h4>Although lower high-density lipoprotein cholesterol (HDL-C) levels are considered a risk factor for cardiovascular disease (CVD), experimental evidence suggest that aging, inflammation, and oxidative stress may remodel HDL-C, leading to dysfunctional HDL-C. Population studies on HDL-C and loss of the glomerular filtration rate (GFR) reported inconsistent results, but they used inaccurate estimates of the GFR and may have been confounded by comorbidity.<h4>Methods</h4>We investigated the association of HDL-C levels with risk of GFR loss in a general population cohort; the participants were aged 50-62 years and did not have diabetes, CVD, or chronic kidney disease (CKD) at baseline. The GFR was measured using iohexol-clearance at baseline (<i>n</i>=1627) and at the follow-up (<i>n</i>=1324) after a median of 5.6 years. We also investigated any possible effect modification by low-grade inflammation, physical activity, and sex.<h4>Results</h4>Higher HDL-C levels were associated with steeper GFR decline rates and increased risk of rapid GFR decline (>3 ml/min per 1.73 m² per year) in multivariable adjusted linear mixed models and logistic regression (-0.64 ml/min per 1.73 m² per year [95% CI -0.99, -0.29; <i>P</i> < 0.001] and odds ratio 2.7 [95% CI 1.4, 5.2; <i>P</i> < 0.001] per doubling in HDL-C). Effect modifications indicated a stronger association between high HDL-C and GFR loss in physically inactive persons, those with low-grade inflammation, and men.<h4>Conclusion</h4>Higher HDL-C levels were independently associated with accelerated GFR loss in a general middle-aged nondiabetic population.Kidney international reports2084-2094https://www.ebi.ac.uk/biostudies/studies/S-EPMC8343778biostudies-literatureAssociation of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population.PMC8343778Melsom TNorvik JVRismo RStefansson VEriksen BOEnoksen ITJenssen TSolbu MDfalseAssociation of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population.<h4>Introduction</h4>Although lower high-density lipoprotein cholesterol (HDL-C) levels are considered a risk factor for cardiovascular disease (CVD), experimental evidence suggest that aging, inflammation, and oxidative stress may remodel HDL-C, leading to dysfunctional HDL-C. Population studies on HDL-C and loss of the glomerular filtration rate (GFR) reported inconsistent results, but they used inaccurate estimates of the GFR and may have been confounded by comorbidity.<h4>Methods</h4>We investigated the association of HDL-C levels with risk of GFR loss in a general population cohort; the participants were aged 50-62 years and did not have diabetes, CVD, or chronic kidney disease (CKD) at baseline. The GFR was measured using iohexol-clearance at baseline (<i>n</i>=1627) and at the follow-up (<i>n</i>=1324) after a median of 5.6 years. We also investigated any possible effect modification by low-grade inflammation, physical activity, and sex.<h4>Results</h4>Higher HDL-C levels were associated with steeper GFR decline rates and increased risk of rapid GFR decline (>3 ml/min per 1.73 m² per year) in multivariable adjusted linear mixed models and logistic regression (-0.64 ml/min per 1.73 m² per year [95% CI -0.99, -0.29; <i>P</i> < 0.001] and odds ratio 2.7 [95% CI 1.4, 5.2; <i>P</i> < 0.001] per doubling in HDL-C). Effect modifications indicated a stronger association between high HDL-C and GFR loss in physically inactive persons, those with low-grade inflammation, and men.<h4>Conclusion</h4>Higher HDL-C levels were independently associated with accelerated GFR loss in a general middle-aged nondiabetic population.2021-01-01T00:00:00Z2021 Aug2024-02-15T11:24:59.665Z2022-02-11T06:54:19.357ZS-EPMC83437783438665710.1016/j.ekir.2021.05.007