{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Forid MS"],"funding":["This work was supported by the Ministry of Education, Malaysia awarded the fundamental Research Grant Scheme"],"pagination":["4634"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8348006"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(15)"],"pubmed_abstract":["This research investigated a UPLC-QTOF/ESI-MS-based phytochemical profiling of <i>Combretum indicum</i> leaf extract (CILEx), and explored its in vitro antioxidant and in vivo antidiabetic effects in a Long-Evans rat model. After a one-week intervention, the animals' blood glucose, lipid profile, and pancreatic architectures were evaluated. UPLC-QTOF/ESI-MS fragmentation of CILEx and its eight docking-guided compounds were further dissected to evaluate their roles using bioinformatics-based network pharmacological tools. Results showed a very promising antioxidative effect of CILEx. Both doses of CILEx were found to significantly (<i>p</i> < 0.05) reduce blood glucose, low-density lipoprotein (LDL), and total cholesterol (TC), and increase high-density lipoprotein (HDL). Pancreatic tissue "],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Pharmacoinformatics and UPLC-QTOF/ESI-MS-Based Phytochemical Screening of <i>Combretum indicum</i> against Oxidative Stress and Alloxan-Induced Diabetes in Long-Evans Rats."],"pmcid":["PMC8348006"],"funding_grant_id":["(FRGS, Reference Number: 04-01-18-1984FR)."],"pubmed_authors":["Aluwi MFFM","Forid MS","Uddin MN","Roy TG","Mohanta MC","Huq AM","Rahman MA","Amiruddin Zakaria Z"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacoinformatics and UPLC-QTOF/ESI-MS-Based Phytochemical Screening of <i>Combretum indicum</i> against Oxidative Stress and Alloxan-Induced Diabetes in Long-Evans Rats.","description":"This research investigated a UPLC-QTOF/ESI-MS-based phytochemical profiling of <i>Combretum indicum</i> leaf extract (CILEx), and explored its in vitro antioxidant and in vivo antidiabetic effects in a Long-Evans rat model. After a one-week intervention, the animals' blood glucose, lipid profile, and pancreatic architectures were evaluated. UPLC-QTOF/ESI-MS fragmentation of CILEx and its eight docking-guided compounds were further dissected to evaluate their roles using bioinformatics-based network pharmacological tools. Results showed a very promising antioxidative effect of CILEx. Both doses of CILEx were found to significantly (<i>p</i> < 0.05) reduce blood glucose, low-density lipoprotein (LDL), and total cholesterol (TC), and increase high-density lipoprotein (HDL). Pancreatic tissue ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-05-05T03:08:38.145Z","creation":"2022-02-11T05:56:40.929Z"},"accession":"S-EPMC8348006","cross_references":{"pubmed":["34361788"],"doi":["10.3390/molecules26154634"]}}