biostudies-literatureForid MSThis work was supported by the Ministry of Education, Malaysia awarded the fundamental Research Grant Scheme4634https://www.ebi.ac.uk/biostudies/studies/S-EPMC8348006biostudies-literatureUnknown26(15)This research investigated a UPLC-QTOF/ESI-MS-based phytochemical profiling of <i>Combretum indicum</i> leaf extract (CILEx), and explored its in vitro antioxidant and in vivo antidiabetic effects in a Long-Evans rat model. After a one-week intervention, the animals' blood glucose, lipid profile, and pancreatic architectures were evaluated. UPLC-QTOF/ESI-MS fragmentation of CILEx and its eight docking-guided compounds were further dissected to evaluate their roles using bioinformatics-based network pharmacological tools. Results showed a very promising antioxidative effect of CILEx. Both doses of CILEx were found to significantly (<i>p</i> < 0.05) reduce blood glucose, low-density lipoprotein (LDL), and total cholesterol (TC), and increase high-density lipoprotein (HDL). Pancreatic tissue Molecules (Basel, Switzerland)Pharmacoinformatics and UPLC-QTOF/ESI-MS-Based Phytochemical Screening of <i>Combretum indicum</i> against Oxidative Stress and Alloxan-Induced Diabetes in Long-Evans Rats.PMC8348006(FRGS, Reference Number: 04-01-18-1984FR).Aluwi MFFMForid MSUddin MNRoy TGMohanta MCHuq AMRahman MAAmiruddin Zakaria ZfalsePharmacoinformatics and UPLC-QTOF/ESI-MS-Based Phytochemical Screening of <i>Combretum indicum</i> against Oxidative Stress and Alloxan-Induced Diabetes in Long-Evans Rats.This research investigated a UPLC-QTOF/ESI-MS-based phytochemical profiling of <i>Combretum indicum</i> leaf extract (CILEx), and explored its in vitro antioxidant and in vivo antidiabetic effects in a Long-Evans rat model. After a one-week intervention, the animals' blood glucose, lipid profile, and pancreatic architectures were evaluated. UPLC-QTOF/ESI-MS fragmentation of CILEx and its eight docking-guided compounds were further dissected to evaluate their roles using bioinformatics-based network pharmacological tools. Results showed a very promising antioxidative effect of CILEx. Both doses of CILEx were found to significantly (<i>p</i> < 0.05) reduce blood glucose, low-density lipoprotein (LDL), and total cholesterol (TC), and increase high-density lipoprotein (HDL). Pancreatic tissue 2021-01-01T00:00:00Z2021 Jul2026-05-05T03:08:38.145Z2022-02-11T05:56:40.929ZS-EPMC83480063436178810.3390/molecules26154634