{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(1)"],"submitter":["Pizzocri M"],"pubmed_abstract":["<h4>Background</h4>The radio- and chemo-resistance of glioblastoma stem-like cells (GSCs), together with their innate tumor-initiating aptitude, make this cell population a crucial target for effective therapies. However, targeting GSCs is hardly difficult and complex, due to the presence of the blood-brain barrier (BBB) and the infiltrative nature of GSCs arousing their dispersion within the brain parenchyma.<h4>Methods</h4>Liposomes (LIPs), surface-decorated with an Apolipoprotein E-modified peptide (mApoE) to enable BBB crossing, were loaded with doxorubicin (DOXO), as paradigm of cytotoxic drug triggering immunogenic cell death (ICD). Patient-derived xenografts (PDXs) obtained by GSC intracranial injection were treated with mApoE-DOXO-LIPs alone or concomitantly with radiation.<h4>Resu"],"journal":["Neuro-oncology advances"],"pagination":["vdab076"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8349181"],"repository":["biostudies-literature"],"pubmed_title":["Radiation and adjuvant drug-loaded liposomes target glioblastoma stem cells and trigger in-situ immune response."],"pmcid":["PMC8349181"],"pubmed_authors":["Tamborini M","Perin A","Matteoli M","Lauranzano E","Rodighiero S","Masserini M","Passoni L","Gregori M","DiMeco F","Pizzocri M","Formicola B","Ungaro F","Stanzani E","Re F","Francolini M"],"additional_accession":[]},"is_claimable":false,"name":"Radiation and adjuvant drug-loaded liposomes target glioblastoma stem cells and trigger in-situ immune response.","description":"<h4>Background</h4>The radio- and chemo-resistance of glioblastoma stem-like cells (GSCs), together with their innate tumor-initiating aptitude, make this cell population a crucial target for effective therapies. However, targeting GSCs is hardly difficult and complex, due to the presence of the blood-brain barrier (BBB) and the infiltrative nature of GSCs arousing their dispersion within the brain parenchyma.<h4>Methods</h4>Liposomes (LIPs), surface-decorated with an Apolipoprotein E-modified peptide (mApoE) to enable BBB crossing, were loaded with doxorubicin (DOXO), as paradigm of cytotoxic drug triggering immunogenic cell death (ICD). Patient-derived xenografts (PDXs) obtained by GSC intracranial injection were treated with mApoE-DOXO-LIPs alone or concomitantly with radiation.<h4>Resu","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan-Dec","modification":"2025-06-01T01:32:44.111Z","creation":"2025-06-01T01:32:44.111Z"},"accession":"S-EPMC8349181","cross_references":{"pubmed":["34377986"],"doi":["10.1093/noajnl/vdab076"]}}