biostudies-literatureUnknown3(1)Pizzocri M<h4>Background</h4>The radio- and chemo-resistance of glioblastoma stem-like cells (GSCs), together with their innate tumor-initiating aptitude, make this cell population a crucial target for effective therapies. However, targeting GSCs is hardly difficult and complex, due to the presence of the blood-brain barrier (BBB) and the infiltrative nature of GSCs arousing their dispersion within the brain parenchyma.<h4>Methods</h4>Liposomes (LIPs), surface-decorated with an Apolipoprotein E-modified peptide (mApoE) to enable BBB crossing, were loaded with doxorubicin (DOXO), as paradigm of cytotoxic drug triggering immunogenic cell death (ICD). Patient-derived xenografts (PDXs) obtained by GSC intracranial injection were treated with mApoE-DOXO-LIPs alone or concomitantly with radiation.<h4>ResuNeuro-oncology advancesvdab076https://www.ebi.ac.uk/biostudies/studies/S-EPMC8349181biostudies-literatureRadiation and adjuvant drug-loaded liposomes target glioblastoma stem cells and trigger in-situ immune response.PMC8349181Tamborini MPerin AMatteoli MLauranzano ERodighiero SMasserini MPassoni LGregori MDiMeco FPizzocri MFormicola BUngaro FStanzani ERe FFrancolini MfalseRadiation and adjuvant drug-loaded liposomes target glioblastoma stem cells and trigger in-situ immune response.<h4>Background</h4>The radio- and chemo-resistance of glioblastoma stem-like cells (GSCs), together with their innate tumor-initiating aptitude, make this cell population a crucial target for effective therapies. However, targeting GSCs is hardly difficult and complex, due to the presence of the blood-brain barrier (BBB) and the infiltrative nature of GSCs arousing their dispersion within the brain parenchyma.<h4>Methods</h4>Liposomes (LIPs), surface-decorated with an Apolipoprotein E-modified peptide (mApoE) to enable BBB crossing, were loaded with doxorubicin (DOXO), as paradigm of cytotoxic drug triggering immunogenic cell death (ICD). Patient-derived xenografts (PDXs) obtained by GSC intracranial injection were treated with mApoE-DOXO-LIPs alone or concomitantly with radiation.<h4>Resu2021-01-01T00:00:00Z2021 Jan-Dec2025-06-01T01:32:44.111Z2025-06-01T01:32:44.111ZS-EPMC83491813437798610.1093/noajnl/vdab076