{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(1)"],"submitter":["Chen S"],"pubmed_abstract":["<h4>Background</h4>Radiotherapy is the mainstay treatment for lung adenocarcinoma, yet remains highly susceptible to resistance. Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles (MNPs) possess the ability to induce biological therapeutic effects. Herein, the current study set out to explore the effects of Fe<sub>3</sub>O<sub>4</sub> MNPs on radiosensitivity of lung adenocarcinoma cells.<h4>Methods</h4>Fe<sub>3</sub>O<sub>4</sub> MNPs loaded with both negatively-charged small interfering RNA against baculoviral IAP repeat containing 5 (siBIRC5) and oligodeoxynucleotide antisense (AS-ODN) to generate co-delivery NPs, followed by evaluation. Gel retardation assay was further performed to determine the binding ability of Fe<sub>3</sub>O<sub>4</sub> MNPs to AS-ODN/siBIRC5. The radiosensitizin"],"journal":["Journal of translational medicine"],"pagination":["337"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8351328"],"repository":["biostudies-literature"],"pubmed_title":["Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticle-enhanced radiotherapy for lung adenocarcinoma via delivery of siBIRC5 and AS-ODN."],"pmcid":["PMC8351328"],"pubmed_authors":["Wang M","Huang D","Wang P","Chu J","Chen S","Meng J","Han F"],"additional_accession":[]},"is_claimable":false,"name":"Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticle-enhanced radiotherapy for lung adenocarcinoma via delivery of siBIRC5 and AS-ODN.","description":"<h4>Background</h4>Radiotherapy is the mainstay treatment for lung adenocarcinoma, yet remains highly susceptible to resistance. Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles (MNPs) possess the ability to induce biological therapeutic effects. Herein, the current study set out to explore the effects of Fe<sub>3</sub>O<sub>4</sub> MNPs on radiosensitivity of lung adenocarcinoma cells.<h4>Methods</h4>Fe<sub>3</sub>O<sub>4</sub> MNPs loaded with both negatively-charged small interfering RNA against baculoviral IAP repeat containing 5 (siBIRC5) and oligodeoxynucleotide antisense (AS-ODN) to generate co-delivery NPs, followed by evaluation. Gel retardation assay was further performed to determine the binding ability of Fe<sub>3</sub>O<sub>4</sub> MNPs to AS-ODN/siBIRC5. The radiosensitizin","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-05T15:09:42.198Z","creation":"2022-02-11T06:42:24.778Z"},"accession":"S-EPMC8351328","cross_references":{"pubmed":["34372869"],"doi":["10.1186/s12967-021-02971-7"]}}