biostudies-literatureUnknown19(1)Chen S<h4>Background</h4>Radiotherapy is the mainstay treatment for lung adenocarcinoma, yet remains highly susceptible to resistance. Fe₃O₄ magnetic nanoparticles (MNPs) possess the ability to induce biological therapeutic effects. Herein, the current study set out to explore the effects of Fe₃O₄ MNPs on radiosensitivity of lung adenocarcinoma cells.<h4>Methods</h4>Fe₃O₄ MNPs loaded with both negatively-charged small interfering RNA against baculoviral IAP repeat containing 5 (siBIRC5) and oligodeoxynucleotide antisense (AS-ODN) to generate co-delivery NPs, followed by evaluation. Gel retardation assay was further performed to determine the binding ability of Fe₃O₄ MNPs to AS-ODN/siBIRC5. The radiosensitizinJournal of translational medicine337https://www.ebi.ac.uk/biostudies/studies/S-EPMC8351328biostudies-literatureFe₃O₄ magnetic nanoparticle-enhanced radiotherapy for lung adenocarcinoma via delivery of siBIRC5 and AS-ODN.PMC8351328Wang MHuang DWang PChu JChen SMeng JHan FfalseFe₃O₄ magnetic nanoparticle-enhanced radiotherapy for lung adenocarcinoma via delivery of siBIRC5 and AS-ODN.<h4>Background</h4>Radiotherapy is the mainstay treatment for lung adenocarcinoma, yet remains highly susceptible to resistance. Fe₃O₄ magnetic nanoparticles (MNPs) possess the ability to induce biological therapeutic effects. Herein, the current study set out to explore the effects of Fe₃O₄ MNPs on radiosensitivity of lung adenocarcinoma cells.<h4>Methods</h4>Fe₃O₄ MNPs loaded with both negatively-charged small interfering RNA against baculoviral IAP repeat containing 5 (siBIRC5) and oligodeoxynucleotide antisense (AS-ODN) to generate co-delivery NPs, followed by evaluation. Gel retardation assay was further performed to determine the binding ability of Fe₃O₄ MNPs to AS-ODN/siBIRC5. The radiosensitizin2021-01-01T00:00:00Z2021 Aug2025-04-05T15:09:42.198Z2022-02-11T06:42:24.778ZS-EPMC83513283437286910.1186/s12967-021-02971-7