{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Pang B"],"pubmed_abstract":["<h4>Objective</h4>Understanding the characteristics of tumor suppressor genes (TSGs) is of great significance for the development of new targeted treatment strategies for non-small cell lung cancer (NSCLC). Therefore, this present article is to explore the underlying molecular mechanism of ZFN24 inhibiting the development of NSCLC.<h4>Methods</h4>We performed RT-PCR and Western blotting for evaluating associated RNA and protein expression. CCK8, colony forming and sphere-forming assays were used to evaluate the proliferation and stemness of NSCLC cells. NSCLC cell senescence was examined by <i>β</i>-galactosidase staining assay. Luciferase assay was performed to evaluate <i>β</i>-catenin transcriptional activity. The effect of ZNF24 on NSCLC cells <i>in vivo</i> was evaluated by the xenogr"],"journal":["Frontiers in oncology"],"pagination":["664369"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8353233"],"repository":["biostudies-literature"],"pubmed_title":["A Novel Tumor Suppressor Gene, ZNF24, Inhibits the Development of NSCLC by Inhibiting the WNT Signaling Pathway to Induce Cell Senescence."],"pmcid":["PMC8353233"],"pubmed_authors":["Pang B","Wang Y","Chang X"],"additional_accession":[]},"is_claimable":false,"name":"A Novel Tumor Suppressor Gene, ZNF24, Inhibits the Development of NSCLC by Inhibiting the WNT Signaling Pathway to Induce Cell Senescence.","description":"<h4>Objective</h4>Understanding the characteristics of tumor suppressor genes (TSGs) is of great significance for the development of new targeted treatment strategies for non-small cell lung cancer (NSCLC). Therefore, this present article is to explore the underlying molecular mechanism of ZFN24 inhibiting the development of NSCLC.<h4>Methods</h4>We performed RT-PCR and Western blotting for evaluating associated RNA and protein expression. CCK8, colony forming and sphere-forming assays were used to evaluate the proliferation and stemness of NSCLC cells. NSCLC cell senescence was examined by <i>β</i>-galactosidase staining assay. Luciferase assay was performed to evaluate <i>β</i>-catenin transcriptional activity. The effect of ZNF24 on NSCLC cells <i>in vivo</i> was evaluated by the xenogr","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-05T15:09:10.769Z","creation":"2022-02-11T06:43:56.157Z"},"accession":"S-EPMC8353233","cross_references":{"pubmed":["34386416"],"doi":["10.3389/fonc.2021.664369"]}}