{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fittolani G"],"funding":["Bundesministerium für Bildung und Forschung","Max-Planck-Gesellschaft"],"pagination":["1981-2025"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8353590"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17"],"pubmed_abstract":["The sequence, length and substitution of a polysaccharide influence its physical and biological properties. Thus, sequence controlled polysaccharides are important targets to establish structure-properties correlations. Polymerization techniques and enzymatic methods have been optimized to obtain samples with well-defined substitution patterns and narrow molecular weight distribution. Chemical synthesis has granted access to polysaccharides with full control over the length. Here, we review the progress towards the synthesis of well-defined polysaccharides. For each class of polysaccharides, we discuss the available synthetic approaches and their current limitations."],"journal":["Beilstein journal of organic chemistry"],"pubmed_title":["Progress and challenges in the synthesis of sequence controlled polysaccharides."],"pmcid":["PMC8353590"],"funding_grant_id":["grant number 13XP5114","MPG-FhG Cooperation Project Glyco3Dysplay"],"pubmed_authors":["Vargova D","Chaube MA","Delbianco M","Tyrikos-Ergas T","Fittolani G"],"additional_accession":[]},"is_claimable":false,"name":"Progress and challenges in the synthesis of sequence controlled polysaccharides.","description":"The sequence, length and substitution of a polysaccharide influence its physical and biological properties. Thus, sequence controlled polysaccharides are important targets to establish structure-properties correlations. Polymerization techniques and enzymatic methods have been optimized to obtain samples with well-defined substitution patterns and narrow molecular weight distribution. Chemical synthesis has granted access to polysaccharides with full control over the length. Here, we review the progress towards the synthesis of well-defined polysaccharides. For each class of polysaccharides, we discuss the available synthetic approaches and their current limitations.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-19T14:20:10.889Z","creation":"2022-02-11T07:19:07.45Z"},"accession":"S-EPMC8353590","cross_references":{"pubmed":["34386106"],"doi":["10.3762/bjoc.17.129"]}}