{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shi H"],"funding":["national basic research program of china","National Natural Science Foundation of China","National Key Research and Development Program of China","State Key Laboratory of Pathogen Biology of Livestock Diseases Open Foundation"],"pagination":["e1009767"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8354476"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(7)"],"pubmed_abstract":["Hypobiosis (facultative developmental arrest) is the most important life-cycle adaptation ensuring survival of parasitic nematodes under adverse conditions. Little is known about such survival mechanisms, although ascarosides (ascarylose with fatty acid-derived side chains) have been reported to mediate the formation of dauer larvae in the free-living nematode Caenorhabditis elegans. Here, we investigated the role of a key gene acox-1, in the larval development of Haemonchus contortus, one of the most important parasitic nematodes that employ hypobiosis as a routine survival mechanism. In this parasite, acox-1 encodes three proteins (ACOXs) that all show a fatty acid oxidation activity in vitro and in vivo, and interact with a peroxin PEX-5 in peroxisomes. In particular, a peroxisomal targ"],"journal":["PLoS pathogens"],"pubmed_title":["Acyl-CoA oxidase ACOX-1 interacts with a peroxin PEX-5 to play roles in larval development of Haemonchus contortus."],"pmcid":["PMC8354476"],"funding_grant_id":["2017YFD0501200","SKLVEB2016KFKT018","32002304","31602041","2015CB150300"],"pubmed_authors":["Du A","Yang Y","Huang X","Yao C","Chen X","Wang Z","Wu F","Shi H","Zhou J","Ma G"],"additional_accession":[]},"is_claimable":false,"name":"Acyl-CoA oxidase ACOX-1 interacts with a peroxin PEX-5 to play roles in larval development of Haemonchus contortus.","description":"Hypobiosis (facultative developmental arrest) is the most important life-cycle adaptation ensuring survival of parasitic nematodes under adverse conditions. Little is known about such survival mechanisms, although ascarosides (ascarylose with fatty acid-derived side chains) have been reported to mediate the formation of dauer larvae in the free-living nematode Caenorhabditis elegans. Here, we investigated the role of a key gene acox-1, in the larval development of Haemonchus contortus, one of the most important parasitic nematodes that employ hypobiosis as a routine survival mechanism. In this parasite, acox-1 encodes three proteins (ACOXs) that all show a fatty acid oxidation activity in vitro and in vivo, and interact with a peroxin PEX-5 in peroxisomes. In particular, a peroxisomal targ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-05-08T00:49:09.583Z","creation":"2022-02-11T06:12:43.387Z"},"accession":"S-EPMC8354476","cross_references":{"pubmed":["34270617"],"doi":["10.1371/journal.ppat.1009767"]}}