biostudies-literatureYamakage HTANITA Healthy Weight Community TrustNational Hospital OrganizationSuzuken Memorial FoundationJapan Society for the Promotion of Science1462-1470https://www.ebi.ac.uk/biostudies/studies/S-EPMC8354504biostudies-literatureUnknown12(8)<h4>Aims/introduction</h4>Weight reduction therapy is the primary treatment to prevent complications of obesity, such as lifestyle diseases and cardiovascular disease; however, to date, useful methods and genetic factors for predicting the outcomes of weight reduction therapy in obese patients have not been established. Protein tyrosine phosphatase 1B (PTP1B), a negative regulator for insulin and leptin signaling, potentially modulates glucose and energy homeostasis. This study aimed to investigate the contribution of PTPN1 polymorphisms on weight reduction and diabetes in obese Japanese patients.<h4>Materials and methods</h4>PTPN1-tagged single-nucleotide polymorphisms (SNPs) rs3787348 and rs6067484 were genotyped in 447 obese Japanese patients from the general population. In this prospecJournal of diabetes investigationAssociation of protein tyrosine phosphatase 1B gene polymorphism with the effects of weight reduction therapy on bodyweight and glycolipid profiles in obese patients.PMC8354504Research Activity start‐up/19K21525Exploratory Research/JP18K19769Scientific Research (C)/JP19K07905Research Activity start-up/19K21525Scientific Research (B)/JP18H02737Clinical research/H26-GENE-03Konishi YMorisaki HMorisaki TMuranaka KHotta KYamakage HMiyamoto YSatoh-Asahara NfalseAssociation of protein tyrosine phosphatase 1B gene polymorphism with the effects of weight reduction therapy on bodyweight and glycolipid profiles in obese patients.<h4>Aims/introduction</h4>Weight reduction therapy is the primary treatment to prevent complications of obesity, such as lifestyle diseases and cardiovascular disease; however, to date, useful methods and genetic factors for predicting the outcomes of weight reduction therapy in obese patients have not been established. Protein tyrosine phosphatase 1B (PTP1B), a negative regulator for insulin and leptin signaling, potentially modulates glucose and energy homeostasis. This study aimed to investigate the contribution of PTPN1 polymorphisms on weight reduction and diabetes in obese Japanese patients.<h4>Materials and methods</h4>PTPN1-tagged single-nucleotide polymorphisms (SNPs) rs3787348 and rs6067484 were genotyped in 447 obese Japanese patients from the general population. In this prospec2021-01-01T00:00:00Z2021 Aug2026-05-07T21:04:49.462Z2022-02-11T08:15:41.182ZS-EPMC83545043340037310.1111/jdi.13492