{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choi Y"],"funding":["NICHD NIH HHS","Markey Cancer Center, University of Kentucky","NIH"],"pagination":["1631-1640"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8354803"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["116(6)"],"pubmed_abstract":["<h4>Objective</h4>To determine the temporal expression of angiotensin-converting enzyme 2 (ACE2), a receptor for SARS-CoV-2, in dominant follicles throughout the periovulatory period in women and the regulatory mechanisms underlying ACE2 expression in human granulosa/lutein cells (hGLC).<h4>Design</h4>Experimental prospective clinical study and laboratory-based investigation.<h4>Setting</h4>University Medical Center and private in vitro fertilization center.<h4>Patient(s)</h4>Thirty premenopausal women undergoing surgery for tubal ligation and 16 premenopausal women undergoing in vitro fertilization.<h4>Intervention(s)</h4>Administration of human chorionic gonadotropin (hCG) and harvesting of preovulatory/ovulatory follicles by timed laparoscopy, and collection of granulosa/lutein cells an"],"journal":["Fertility and sterility"],"pubmed_title":["Ovulatory upregulation of angiotensin-converting enzyme 2, a receptor for SARS-CoV-2, in dominant follicles of the human ovary."],"pmcid":["PMC8354803"],"funding_grant_id":["R03 HD095098","P30CA177558","R01HD096077","P01 HD071875","P01HD71875","R01 HD096077","R03HD095098"],"pubmed_authors":["Brannstrom M","Jo M","Curry TE","Choi Y","Jeon H","Akin JW"],"additional_accession":[]},"is_claimable":false,"name":"Ovulatory upregulation of angiotensin-converting enzyme 2, a receptor for SARS-CoV-2, in dominant follicles of the human ovary.","description":"<h4>Objective</h4>To determine the temporal expression of angiotensin-converting enzyme 2 (ACE2), a receptor for SARS-CoV-2, in dominant follicles throughout the periovulatory period in women and the regulatory mechanisms underlying ACE2 expression in human granulosa/lutein cells (hGLC).<h4>Design</h4>Experimental prospective clinical study and laboratory-based investigation.<h4>Setting</h4>University Medical Center and private in vitro fertilization center.<h4>Patient(s)</h4>Thirty premenopausal women undergoing surgery for tubal ligation and 16 premenopausal women undergoing in vitro fertilization.<h4>Intervention(s)</h4>Administration of human chorionic gonadotropin (hCG) and harvesting of preovulatory/ovulatory follicles by timed laparoscopy, and collection of granulosa/lutein cells an","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-05-29T19:05:25.926Z","creation":"2022-02-11T13:19:21.477Z"},"accession":"S-EPMC8354803","cross_references":{"pubmed":["34538460"],"doi":["10.1016/j.fertnstert.2021.08.009"]}}