biostudies-literatureChoi YNICHD NIH HHSMarkey Cancer Center, University of KentuckyNIH1631-1640https://www.ebi.ac.uk/biostudies/studies/S-EPMC8354803biostudies-literatureUnknown116(6)<h4>Objective</h4>To determine the temporal expression of angiotensin-converting enzyme 2 (ACE2), a receptor for SARS-CoV-2, in dominant follicles throughout the periovulatory period in women and the regulatory mechanisms underlying ACE2 expression in human granulosa/lutein cells (hGLC).<h4>Design</h4>Experimental prospective clinical study and laboratory-based investigation.<h4>Setting</h4>University Medical Center and private in vitro fertilization center.<h4>Patient(s)</h4>Thirty premenopausal women undergoing surgery for tubal ligation and 16 premenopausal women undergoing in vitro fertilization.<h4>Intervention(s)</h4>Administration of human chorionic gonadotropin (hCG) and harvesting of preovulatory/ovulatory follicles by timed laparoscopy, and collection of granulosa/lutein cells anFertility and sterilityOvulatory upregulation of angiotensin-converting enzyme 2, a receptor for SARS-CoV-2, in dominant follicles of the human ovary.PMC8354803R03 HD095098P30CA177558R01HD096077P01 HD071875P01HD71875R01 HD096077R03HD095098Brannstrom MJo MCurry TEChoi YJeon HAkin JWfalseOvulatory upregulation of angiotensin-converting enzyme 2, a receptor for SARS-CoV-2, in dominant follicles of the human ovary.<h4>Objective</h4>To determine the temporal expression of angiotensin-converting enzyme 2 (ACE2), a receptor for SARS-CoV-2, in dominant follicles throughout the periovulatory period in women and the regulatory mechanisms underlying ACE2 expression in human granulosa/lutein cells (hGLC).<h4>Design</h4>Experimental prospective clinical study and laboratory-based investigation.<h4>Setting</h4>University Medical Center and private in vitro fertilization center.<h4>Patient(s)</h4>Thirty premenopausal women undergoing surgery for tubal ligation and 16 premenopausal women undergoing in vitro fertilization.<h4>Intervention(s)</h4>Administration of human chorionic gonadotropin (hCG) and harvesting of preovulatory/ovulatory follicles by timed laparoscopy, and collection of granulosa/lutein cells an2021-01-01T00:00:00Z2021 Dec2025-05-29T19:05:25.926Z2022-02-11T13:19:21.477ZS-EPMC83548033453846010.1016/j.fertnstert.2021.08.009