{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ricker E"],"funding":["Peter Jay Sharp Foundation","Marina Kellen French and the Anna-Maria and Stephen Kellen Foundation","Rheumatology Research Foundation","U.S. Department of Health &amp; Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","Barbara Volcker Center Giammaria Giuliani and the Ambrose Monell Foundation","Lupus Research Alliance","NCI NIH HHS","NIAMS NIH HHS","NIH HHS"],"pagination":["4813"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8355159"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Differences in immune responses to viruses and autoimmune diseases such as systemic lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are a population of CD11c<sup>+</sup>T-bet<sup>+</sup> B cells critical for antiviral responses and autoimmune disorders. Absence of DEF6 and SWAP-70, two homologous guanine exchange factors, in double-knock-out (DKO) mice leads to a lupus-like syndrome in females marked by accumulation of ABCs. Here we demonstrate that DKO ABCs show sex-specific differences in cell number, upregulation of an ISG signature, and further differentiation. DKO ABCs undergo oligoclonal expansion and differentiate into both CD11c<sup>+</sup> and CD11c<sup>-</sup> effector B cell populations with pathogenic and pro-inflammatory function as demonstra"],"journal":["Nature communications"],"pubmed_title":["Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice."],"pmcid":["PMC8355159"],"funding_grant_id":["P30 CA016520","AR064883","T32 AR071302","R01 AR064883","AR070146","R01 AR070146","S10 OD019986"],"pubmed_authors":["Ricker E","Gupta S","Jenkins D","Rivera-Correa J","Pannellini T","Manni M","Sculco PK","Flores-Castro D","Jessberger R","Meng W","Rosenfeld AM","Prak ETL","Pernis AB","Chinenov Y","Bachu M"],"additional_accession":[]},"is_claimable":false,"name":"Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice.","description":"Differences in immune responses to viruses and autoimmune diseases such as systemic lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are a population of CD11c<sup>+</sup>T-bet<sup>+</sup> B cells critical for antiviral responses and autoimmune disorders. Absence of DEF6 and SWAP-70, two homologous guanine exchange factors, in double-knock-out (DKO) mice leads to a lupus-like syndrome in females marked by accumulation of ABCs. Here we demonstrate that DKO ABCs show sex-specific differences in cell number, upregulation of an ISG signature, and further differentiation. DKO ABCs undergo oligoclonal expansion and differentiate into both CD11c<sup>+</sup> and CD11c<sup>-</sup> effector B cell populations with pathogenic and pro-inflammatory function as demonstra","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2026-05-08T13:48:16.644Z","creation":"2025-05-18T11:57:36.744Z"},"accession":"S-EPMC8355159","cross_references":{"pubmed":["34376664"],"doi":["10.1038/s41467-021-25102-8"]}}