{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou Y"],"funding":["NIAAA NIH HHS"],"pagination":["136092"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8355176"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["760"],"pubmed_abstract":["Though it is well known that G protein-coupled receptor kinase 2 [GRK2] is involved in regulation of mu opioid receptor [MOR] desensitization and morphine-related behaviors, the potential role of GRK2 in regulation of kappa opioid receptor [KOR] functions in vivo has not been established yet. A couple of recent studies have found that GRK2 activity desensitizes KOR functions via decreasing G protein-coupled signaling with sensitizing arrestin-coupled signaling. Nalfurafine, a G protein-biased KOR full agonist, produces an inhibitory effect on alcohol intake in mice, with fewer side effects (sedation, aversion, or anxiety/depression-like behaviors). Using RNA sequencing (RNA-seq) analysis, we first identified that nuclear transcript level of grk2 [adrbk1] (but not other grks) was significan"],"journal":["Neuroscience letters"],"pubmed_title":["Involvement of GRK2 in modulating nalfurafine-induced reduction of excessive alcohol drinking in mice."],"pmcid":["PMC8355176"],"funding_grant_id":["R03 AA021970"],"pubmed_authors":["Liang Y","Zhou Y"],"additional_accession":[]},"is_claimable":false,"name":"Involvement of GRK2 in modulating nalfurafine-induced reduction of excessive alcohol drinking in mice.","description":"Though it is well known that G protein-coupled receptor kinase 2 [GRK2] is involved in regulation of mu opioid receptor [MOR] desensitization and morphine-related behaviors, the potential role of GRK2 in regulation of kappa opioid receptor [KOR] functions in vivo has not been established yet. A couple of recent studies have found that GRK2 activity desensitizes KOR functions via decreasing G protein-coupled signaling with sensitizing arrestin-coupled signaling. Nalfurafine, a G protein-biased KOR full agonist, produces an inhibitory effect on alcohol intake in mice, with fewer side effects (sedation, aversion, or anxiety/depression-like behaviors). Using RNA sequencing (RNA-seq) analysis, we first identified that nuclear transcript level of grk2 [adrbk1] (but not other grks) was significan","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-27T01:47:55.119Z","creation":"2025-04-06T18:20:44.389Z"},"accession":"S-EPMC8355176","cross_references":{"pubmed":["34197905"],"doi":["10.1016/j.neulet.2021.136092"]}}