biostudies-literatureUnknown12Cestellos-Blanco SNational Aeronautics and Space AdministrationProviding life-support materials to crewed space exploration missions is pivotal for mission success. However, as missions become more distant and extensive, obtaining these materials from <i>in situ</i> resource utilization is paramount. The combination of microorganisms with electrochemical technologies offers a platform for the production of critical chemicals and materials from CO₂ and H₂O, two compounds accessible on a target destination like Mars. One such potential commodity is poly(3-hydroxybutyrate) (PHB), a common biopolyester targeted for additive manufacturing of durable goods. Here, we present an integrated two-module process for the production of PHB from CO₂. An autotrophic <i>Sporomusa ovata (S. ovata)</i> process converts CO₂ to Frontiers in microbiology700010https://www.ebi.ac.uk/biostudies/studies/S-EPMC8355900biostudies-literatureProduction of PHB From CO₂-Derived Acetate With Minimal Processing Assessed for Space Biomanufacturing.PMC8355900Sander KBAbel AJKim JMCestellos-Blanco SClark DSArkin APFriedline SYang PfalseProduction of PHB From CO₂-Derived Acetate With Minimal Processing Assessed for Space Biomanufacturing.Providing life-support materials to crewed space exploration missions is pivotal for mission success. However, as missions become more distant and extensive, obtaining these materials from <i>in situ</i> resource utilization is paramount. The combination of microorganisms with electrochemical technologies offers a platform for the production of critical chemicals and materials from CO₂ and H₂O, two compounds accessible on a target destination like Mars. One such potential commodity is poly(3-hydroxybutyrate) (PHB), a common biopolyester targeted for additive manufacturing of durable goods. Here, we present an integrated two-module process for the production of PHB from CO₂. An autotrophic <i>Sporomusa ovata (S. ovata)</i> process converts CO₂ to 2021-01-01T00:00:00Z20212025-04-20T02:05:02.611Z2022-02-11T07:26:46.793ZS-EPMC83559003439404410.3389/fmicb.2021.700010