biostudies-literatureRosenthal MNational Cancer InstituteNCI NIH HHS690-698https://www.ebi.ac.uk/biostudies/studies/S-EPMC8356859biostudies-literatureUnknown6(4)<h4>Importance</h4>This study reports the impact of laser surgery on quality of life in patients with oral cavity lesions.<h4>Objective</h4>To compare postoperative pain and quality of life in patients treated with flexible fiberoptic CO₂ laser vs electrocautery in patients with oral cavity precancerous lesions and early stage cancers.<h4>Design</h4>Randomized controlled trial.<h4>Setting</h4>Single center.<h4>Participants</h4>Patients with premalignant oral cavity lesions and early stage oral cancer.<h4>Intervention</h4>Patients were randomized to have surgical resection using either flexible fiber carbon dioxide laser (Laser) or electrocautery (EC). The patients were then followed over a period of 28 days to assess for outcomes including pain, quality of life, performance statLaryngoscope investigative otolaryngologyFlexible fiber-based CO₂ laser vs monopolar cautery for resection of oral cavity lesions: A single center randomized controlled trial assessing pain and quality of life following surgery.PMC8356859P30 CA008748Wong RJCohen MAMorris LGTPatel SBaser REShah JPBoyle JOSingh BGanly IMigliacci JRosenthal MfalseFlexible fiber-based CO₂ laser vs monopolar cautery for resection of oral cavity lesions: A single center randomized controlled trial assessing pain and quality of life following surgery.<h4>Importance</h4>This study reports the impact of laser surgery on quality of life in patients with oral cavity lesions.<h4>Objective</h4>To compare postoperative pain and quality of life in patients treated with flexible fiberoptic CO₂ laser vs electrocautery in patients with oral cavity precancerous lesions and early stage cancers.<h4>Design</h4>Randomized controlled trial.<h4>Setting</h4>Single center.<h4>Participants</h4>Patients with premalignant oral cavity lesions and early stage oral cancer.<h4>Intervention</h4>Patients were randomized to have surgical resection using either flexible fiber carbon dioxide laser (Laser) or electrocautery (EC). The patients were then followed over a period of 28 days to assess for outcomes including pain, quality of life, performance stat2021-01-01T00:00:00Z2021 Aug2026-05-03T03:12:51.783Z2022-02-11T08:32:27.165ZS-EPMC83568593440149310.1002/lio2.572