{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garcia-Keller C"],"funding":["NIDA NIH HHS","Foundation for the National Institutes of Health"],"pagination":["1848-1856"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8357931"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(10)"],"pubmed_abstract":["Exposure to acute stress can increase vulnerability to develop or express many psychiatric disorders, including post-traumatic stress disorder. We hypothesized that stress-induced psychiatric vulnerability is associated with enduring neuroplasticity in the nucleus accumbens core because stress exposure can alter drug addiction-related behaviors that are associated with accumbens synaptic plasticity. We used a single 2-h stress session and 3 weeks later exposed male and female rats to stress-conditioned odors in a modified defensive burying task, and quantified both active and avoidant coping strategies. We measured corticosterone, dendritic spine and astrocyte morphology in accumbens, and examined reward sensitivity using a sucrose two-bottle choice and operant sucrose self-administration."],"journal":["Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"],"pubmed_title":["Behavioral and accumbens synaptic plasticity induced by cues associated with restraint stress."],"pmcid":["PMC8357931"],"funding_grant_id":["F32 DA044782","DA016511","K99 DA047426","R01 DA033049","DA033049","K99DA047426-01A1","R00 DA047426"],"pubmed_authors":["Hopkins JL","Kalivas PW","Garcia-Keller C","Kruyer A","Kearns AM","Hodebourg R","Carter JS","Reichel CM"],"additional_accession":[]},"is_claimable":false,"name":"Behavioral and accumbens synaptic plasticity induced by cues associated with restraint stress.","description":"Exposure to acute stress can increase vulnerability to develop or express many psychiatric disorders, including post-traumatic stress disorder. We hypothesized that stress-induced psychiatric vulnerability is associated with enduring neuroplasticity in the nucleus accumbens core because stress exposure can alter drug addiction-related behaviors that are associated with accumbens synaptic plasticity. We used a single 2-h stress session and 3 weeks later exposed male and female rats to stress-conditioned odors in a modified defensive burying task, and quantified both active and avoidant coping strategies. We measured corticosterone, dendritic spine and astrocyte morphology in accumbens, and examined reward sensitivity using a sucrose two-bottle choice and operant sucrose self-administration.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-03-15T11:17:05.443Z","creation":"2025-04-04T09:37:19.249Z"},"accession":"S-EPMC8357931","cross_references":{"pubmed":["34226657"],"doi":["10.1038/s41386-021-01074-7"]}}