{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Cho EB"],"funding":["National Research Foundation of Korea"],"pubmed_abstract":["<h4>Background</h4>Clear associations have been found between vitamin D deficiency and several autoimmune diseases including multiple sclerosis (MS). However, the benefits of vitamin D supplementation on disease management remain a matter of debate.<h4>Objective and methods</h4>Patients with MS (<i>N</i>=12) and neuromyelitis optica spectrum disorder (NMOSD; <i>N</i>=12) were enrolled along with 15 healthy controls. Changes in lymphocyte subset proportions during stimulation of their peripheral blood mononuclear cells (PBMCs) with the active form of vitamin D, 1,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>), and correlations with serum concentrations of the vitamin D precursor 25-hydroxyvitamin D<sub>3</sub> (serum 25(OH)D<sub>3</sub>) were explored. The impact of 1"],"journal":["Frontiers in immunology"],"pagination":["677041"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8358328"],"repository":["biostudies-literature"],"pubmed_title":["Effects of Vitamin D and Dexamethasone on Lymphocyte Proportions and Their Associations With Serum Concentrations of 25-Hydroxyvitamin D<sub>3</sub> <i>In Vitro</i> in Patients With Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder."],"pmcid":["PMC8358328"],"pubmed_authors":["Cho EB","Kwon S","Shin JH","Min JH","Seok JM","Kim J","Kim BJ"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Vitamin D and Dexamethasone on Lymphocyte Proportions and Their Associations With Serum Concentrations of 25-Hydroxyvitamin D<sub>3</sub> <i>In Vitro</i> in Patients With Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder.","description":"<h4>Background</h4>Clear associations have been found between vitamin D deficiency and several autoimmune diseases including multiple sclerosis (MS). However, the benefits of vitamin D supplementation on disease management remain a matter of debate.<h4>Objective and methods</h4>Patients with MS (<i>N</i>=12) and neuromyelitis optica spectrum disorder (NMOSD; <i>N</i>=12) were enrolled along with 15 healthy controls. Changes in lymphocyte subset proportions during stimulation of their peripheral blood mononuclear cells (PBMCs) with the active form of vitamin D, 1,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>), and correlations with serum concentrations of the vitamin D precursor 25-hydroxyvitamin D<sub>3</sub> (serum 25(OH)D<sub>3</sub>) were explored. The impact of 1","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-05T15:08:48.787Z","creation":"2022-02-11T07:18:34.325Z"},"accession":"S-EPMC8358328","cross_references":{"pubmed":["34394078"],"doi":["10.3389/fimmu.2021.677041"]}}