biostudies-literatureUnknown12Cho EBNational Research Foundation of Korea<h4>Background</h4>Clear associations have been found between vitamin D deficiency and several autoimmune diseases including multiple sclerosis (MS). However, the benefits of vitamin D supplementation on disease management remain a matter of debate.<h4>Objective and methods</h4>Patients with MS (<i>N</i>=12) and neuromyelitis optica spectrum disorder (NMOSD; <i>N</i>=12) were enrolled along with 15 healthy controls. Changes in lymphocyte subset proportions during stimulation of their peripheral blood mononuclear cells (PBMCs) with the active form of vitamin D, 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃), and correlations with serum concentrations of the vitamin D precursor 25-hydroxyvitamin D₃ (serum 25(OH)D₃) were explored. The impact of 1Frontiers in immunology677041https://www.ebi.ac.uk/biostudies/studies/S-EPMC8358328biostudies-literatureEffects of Vitamin D and Dexamethasone on Lymphocyte Proportions and Their Associations With Serum Concentrations of 25-Hydroxyvitamin D₃ <i>In Vitro</i> in Patients With Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder.PMC8358328Cho EBKwon SShin JHMin JHSeok JMKim JKim BJfalseEffects of Vitamin D and Dexamethasone on Lymphocyte Proportions and Their Associations With Serum Concentrations of 25-Hydroxyvitamin D₃ <i>In Vitro</i> in Patients With Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder.<h4>Background</h4>Clear associations have been found between vitamin D deficiency and several autoimmune diseases including multiple sclerosis (MS). However, the benefits of vitamin D supplementation on disease management remain a matter of debate.<h4>Objective and methods</h4>Patients with MS (<i>N</i>=12) and neuromyelitis optica spectrum disorder (NMOSD; <i>N</i>=12) were enrolled along with 15 healthy controls. Changes in lymphocyte subset proportions during stimulation of their peripheral blood mononuclear cells (PBMCs) with the active form of vitamin D, 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃), and correlations with serum concentrations of the vitamin D precursor 25-hydroxyvitamin D₃ (serum 25(OH)D₃) were explored. The impact of 12021-01-01T00:00:00Z20212025-04-05T15:08:48.787Z2022-02-11T07:18:34.325ZS-EPMC83583283439407810.3389/fimmu.2021.677041