{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(8)"],"submitter":["Augusto LA"],"pubmed_abstract":["<i>Enterobacter cloacae</i> complex species are involved in infections among critically ill patients. After a recent <i>E.cloacae</i> outbreak of fulminant neonatal septic shock, we conducted a study to determine whether septic shock severity and its lethal consequence are related to structural features of the endotoxin (lipopolysaccharide [LPS]) of the strains isolated from hospitalized infants and more specifically its lipid A region. It appeared that the LPSs are very heterogeneous, carrying fifteen different molecular species of lipid A. The virulence was correlated with a structural feature identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry and gas chromatography coupled with mass spectrometry: the presence of 2-hydroxymyristic acid as a seconda"],"journal":["iScience"],"pagination":["102916"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8361193"],"repository":["biostudies-literature"],"pubmed_title":["Presence of 2-hydroxymyristate on endotoxins is associated with death in neonates with <i>Enterobacter cloacae</i> complex septic shock."],"pmcid":["PMC8361193"],"pubmed_authors":["De Luca D","Alonso EH","Tissieres P","Doucet-Populaire F","Augusto LA","Semaan N","Breton A","Chaby R","Gera S","Barreault S","Faraut-Derouin V","Bourgeois-Nicolaos N"],"additional_accession":[]},"is_claimable":false,"name":"Presence of 2-hydroxymyristate on endotoxins is associated with death in neonates with <i>Enterobacter cloacae</i> complex septic shock.","description":"<i>Enterobacter cloacae</i> complex species are involved in infections among critically ill patients. After a recent <i>E.cloacae</i> outbreak of fulminant neonatal septic shock, we conducted a study to determine whether septic shock severity and its lethal consequence are related to structural features of the endotoxin (lipopolysaccharide [LPS]) of the strains isolated from hospitalized infants and more specifically its lipid A region. It appeared that the LPSs are very heterogeneous, carrying fifteen different molecular species of lipid A. The virulence was correlated with a structural feature identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry and gas chromatography coupled with mass spectrometry: the presence of 2-hydroxymyristic acid as a seconda","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2026-05-09T00:05:09.638Z","creation":"2022-02-11T08:58:00.75Z"},"accession":"S-EPMC8361193","cross_references":{"pubmed":["34409274"],"doi":["10.1016/j.isci.2021.102916"]}}