{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["97(4)"],"submitter":["Kumar A"],"pubmed_abstract":["<h4>Objective</h4>To undertake a genome-wide association study (GWAS) to identify genetic variants for stroke in an Indian population.<h4>Methods</h4>In a hospital-based case-control study, 8 teaching hospitals in India recruited 4,088 participants, including 1,609 stroke cases. Imputed genetic variants were tested for association with stroke subtypes using both single-marker and gene-based tests. Association with vascular risk factors was performed with logistic regression. Various databases were searched for replication, functional annotation, and association with related traits. Status of candidate genes previously reported in the Indian population was also checked.<h4>Results</h4>Associations of vascular risk factors with stroke were similar to previous reports and show modifiable risk"],"journal":["Neurology"],"pagination":["e345-e356"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8362360"],"repository":["biostudies-literature"],"pubmed_title":["Association of SUMOylation Pathway Genes With Stroke in a Genome-Wide Association Study in India."],"pmcid":["PMC8362360"],"pubmed_authors":["Vivekanandhan S","Chaudhary N","Gupta S","Srivastava AK","Sharma P","Sharma S","Anand KS","Kaul B","Dabla S","Agrawal CS","Mohania D","Sylaja PN","Chauhan G","Raghavan S","Gorthi SP","Hazarika A","Prasad K","Maheshwari A","Vibha D","Kaushik S","Sagar R","Raj R","Kumar A","Yadav RK"],"additional_accession":[]},"is_claimable":false,"name":"Association of SUMOylation Pathway Genes With Stroke in a Genome-Wide Association Study in India.","description":"<h4>Objective</h4>To undertake a genome-wide association study (GWAS) to identify genetic variants for stroke in an Indian population.<h4>Methods</h4>In a hospital-based case-control study, 8 teaching hospitals in India recruited 4,088 participants, including 1,609 stroke cases. Imputed genetic variants were tested for association with stroke subtypes using both single-marker and gene-based tests. Association with vascular risk factors was performed with logistic regression. Various databases were searched for replication, functional annotation, and association with related traits. Status of candidate genes previously reported in the Indian population was also checked.<h4>Results</h4>Associations of vascular risk factors with stroke were similar to previous reports and show modifiable risk","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2025-06-01T02:53:58.715Z","creation":"2025-06-01T02:53:58.715Z"},"accession":"S-EPMC8362360","cross_references":{"pubmed":["34031191"],"doi":["10.1212/wnl.0000000000012258","10.1212/WNL.0000000000012258"]}}