{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(1)"],"submitter":["Honda F"],"funding":["Japan Agency for Medical Research and Development"],"pubmed_abstract":["Background
Our previous studies reveal that CCL18-CCR8 chemokine axis is upregulated in patients of immunoglobulin G4-related disease (IgG4-RD), suggesting that the CCL18-CCR8 axis is implicated in the etiology of IgG4-RD, although whether this axis has a potential as a therapeutic target remains unclear. Our purpose was to clarify the pathogenic roles and therapeutic potential of the murine CCL8 (analog of human CCL18)-CCR8 axis by using an animal model of IgG4-RD (LAT Y136F knockin mice; LAT mice).Methods
We compared the infiltration of inflammatory cells and the fibrosis of the salivary glands of 6-week-old LAT mice and littermate mice. The expressions of Ccl8 and Ccr8 were also compared. Next, we investigated the therapeutic effects of intravenous administration of anti"],"journal":["Arthritis research & therapy"],"pagination":["214"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8364087"],"repository":["biostudies-literature"],"pubmed_title":["Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine model of IgG4-related sialadenitis."],"pmcid":["PMC8364087"],"pubmed_authors":["Tsuboi H","Kawano M","Ono Y","Asano K","Honda F","Yamada K","Malissen B","Ito K","Kondo Y","Malissen M","Abe S","Matsumoto I","Takahashi H","Tanaka M","Sumida T"],"additional_accession":[]},"is_claimable":false,"name":"Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine model of IgG4-related sialadenitis.","description":"Background
Our previous studies reveal that CCL18-CCR8 chemokine axis is upregulated in patients of immunoglobulin G4-related disease (IgG4-RD), suggesting that the CCL18-CCR8 axis is implicated in the etiology of IgG4-RD, although whether this axis has a potential as a therapeutic target remains unclear. Our purpose was to clarify the pathogenic roles and therapeutic potential of the murine CCL8 (analog of human CCL18)-CCR8 axis by using an animal model of IgG4-RD (LAT Y136F knockin mice; LAT mice).Methods
We compared the infiltration of inflammatory cells and the fibrosis of the salivary glands of 6-week-old LAT mice and littermate mice. The expressions of Ccl8 and Ccr8 were also compared. Next, we investigated the therapeutic effects of intravenous administration of anti","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-04T21:28:52.407Z","creation":"2022-02-11T08:14:21.742Z"},"accession":"S-EPMC8364087","cross_references":{"pubmed":["34391459"],"doi":["10.1186/s13075-021-02597-6"]}}