{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chu C"],"funding":["NCI NIH HHS","National Institutes of Health","Novartis"],"pagination":["732-746"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8364501"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(9)"],"pubmed_abstract":["E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent kinase 2 (CDK2) and drive cell cycle progression by phosphorylating several cellular proteins. Abnormally elevated activity of cyclin E-CDK2 has been documented in many human tumor types. Moreover, cyclin E overexpression mediates resistance of tumor cells to various therapeutic agents. Recent work has revealed that the role of cyclin E extends well beyond cell proliferation and tumorigenesis, and it may regulate a diverse array of physiological and pathological processes. In this review, we discuss these various cyclin E functions and the potential for therapeutic targeting of cyclin E and cyclin E-CDK2 kinase"],"journal":["Trends in cell biology"],"pubmed_title":["Cyclin E in normal physiology and disease states."],"pmcid":["PMC8364501"],"funding_grant_id":["P01 CA250959","R01CA202634","R01 CA239660","R50 CA243769","R01 CA202634","R01 CA236226","R01CA236226"],"pubmed_authors":["Sicinski P","Chu C","Geng Y","Zhou Y"],"additional_accession":[]},"is_claimable":false,"name":"Cyclin E in normal physiology and disease states.","description":"E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent kinase 2 (CDK2) and drive cell cycle progression by phosphorylating several cellular proteins. Abnormally elevated activity of cyclin E-CDK2 has been documented in many human tumor types. Moreover, cyclin E overexpression mediates resistance of tumor cells to various therapeutic agents. Recent work has revealed that the role of cyclin E extends well beyond cell proliferation and tumorigenesis, and it may regulate a diverse array of physiological and pathological processes. In this review, we discuss these various cyclin E functions and the potential for therapeutic targeting of cyclin E and cyclin E-CDK2 kinase","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-05T00:42:34.567Z","creation":"2024-11-21T10:29:59.425Z"},"accession":"S-EPMC8364501","cross_references":{"pubmed":["34052101"],"doi":["10.1016/j.tcb.2021.05.001"]}}