{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu W"],"funding":["National Key R&amp;D Program of China to Hongwen Zhou","Health Department Fund Projects of Jiangsu Province","National Natural Sciences Foundation of China"],"pagination":["1316-1326"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8366658"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["53(1)"],"pubmed_abstract":["<h4>Objective</h4>This study aimed to investigate the effects of <i>PPM1K</i> rs1440581 and rs7678928 single nucleotide polymorphisms (SNPs) on the serum branched-chain amino acids (BCAAs) levels and cardiovascular disease (CVD) risk.<h4>Methods</h4>Anthropometric and biochemical examinations were performed at baseline and the end of 4 years in 234 individuals who were randomly recruited from the <i>Diabetes Prevention Programme in Huai'an</i> and received lifestyle intervention and follow up for 4 years. Serum BCAAs (leucine, isoleucine and valine (Val)) levels were measured by hydrophilic interaction chromatography-tandem mass spectrometric method and the <i>PPM1K</i> rs1440581 and rs7678928 were detected by high-throughput SNP genotyping at baseline. The associations of rs1440581 and rs"],"journal":["Annals of medicine"],"pubmed_title":["Effects of <i>PPM1K</i> rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease."],"pmcid":["PMC8366658"],"funding_grant_id":["81700776","2018YFA0506904","Z201317"],"pubmed_authors":["Liu Z","Li J","Li S","Hu W","Qi X","Lu Y","Yu W","Wen S","Hao H","Wang X","Zhou H"],"additional_accession":[]},"is_claimable":false,"name":"Effects of <i>PPM1K</i> rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease.","description":"<h4>Objective</h4>This study aimed to investigate the effects of <i>PPM1K</i> rs1440581 and rs7678928 single nucleotide polymorphisms (SNPs) on the serum branched-chain amino acids (BCAAs) levels and cardiovascular disease (CVD) risk.<h4>Methods</h4>Anthropometric and biochemical examinations were performed at baseline and the end of 4 years in 234 individuals who were randomly recruited from the <i>Diabetes Prevention Programme in Huai'an</i> and received lifestyle intervention and follow up for 4 years. Serum BCAAs (leucine, isoleucine and valine (Val)) levels were measured by hydrophilic interaction chromatography-tandem mass spectrometric method and the <i>PPM1K</i> rs1440581 and rs7678928 were detected by high-throughput SNP genotyping at baseline. The associations of rs1440581 and rs","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-04T13:43:15.645Z","creation":"2022-02-11T08:17:42.819Z"},"accession":"S-EPMC8366658","cross_references":{"pubmed":["34382495"],"doi":["10.1080/07853890.2021.1965204"]}}